- Burn stubborn fat without jitters or crashes — perfect for all-day use.
- Boosts metabolism and thyroid function for 24/7 fat-burning mode.
- Curbs cravings and supports clean digestion to eliminate bloating & food coma.
- FREE & Fast Shipping Straight To Your Doorstep On Orders Over $99+
- Burn stubborn fat without jitters or crashes — perfect for all-day use.
- Boosts metabolism and thyroid function for 24/7 fat-burning mode.
- Curbs cravings and supports clean digestion to eliminate bloating & food coma.
- FREE & Fast Shipping Straight To Your Doorstep On Orders Over $99+
Here's Why Your Fat Burner Is Actually Making You Fatter
WARNING: This controversial Shred method unlocks fast, sustained fat loss — without the burnout.
That jittery, anxious feeling? That's your stress hormones SKYROCKETING.
And when stress hormones spike, your body does the exact opposite of what you want:
It holds onto fat like its life depends on it.☠️
You see, most fat burners are just caffeine bombs...
Designed to make you feel like something's happening. Meanwhile, your cortisol is through the roof, your appetite control is shot, and your metabolism is actually SLOWING DOWN.
It's like trying to lose weight by drinking 6 cups of coffee and wondering
why you're exhausted, hungry, and not losing a damn pound.
Here's Why Your Fat Burner Is Actually Making You Fatter
WARNING: This controversial Shred method unlocks fast, sustained fat loss — without the burnout.
That jittery, anxious feeling? That's your stress hormones SKYROCKETING.
And when stress hormones spike, your body does the exact opposite of what you want:
It holds onto fat like its life depends on it.☠️
You see, most fat burners
are just caffeine bombs...
Designed to make you feel like something's happening. Meanwhile, your cortisol is through the roof, your appetite control is shot, and your metabolism is actually SLOWING DOWN.
It's like trying to lose weight by drinking 6 cups of coffee and wondering
why you're exhausted, hungry, and not losing a damn pound.
The Japanese "Heat Switch"
Discovery That Changes Everything
In 2018, researchers in Japan made a breakthrough discovery about a specific type of fat tissue called "brown adipose tissue" (BAT).
- Uses fat and sugar for energy
- Burns calories via heat (UCP1 activation)
- Works without exercise needed
Unlike regular fat that just sits there looking ugly, brown fat is like a metabolic furnace that burns calories 24/7 - even while you sleep. (Aboouf et al., 2023)
Here's the crazy part...
Most people have this fat-burning tissue completely "switched off."
Traditional fat burners actually SUPPRESS this natural fat-burning system by flooding your body with stress hormones.
But what if you could flip the switch back ON?
What if you could activate your body's natural fat-burning furnace WITHOUT the jitters, anxiety, or crashes?
That's exactly what SHRED does:
The Japanese "Heat Switch"
Discovery That Changes Everything
In 2018, researchers in Japan made a breakthrough discovery about a specific type of fat tissue called "brown adipose tissue" (BAT).
- Uses fat and sugar for energy
- Burns calories via heat (UCP1 activation)
- Works without exercise needed
Unlike regular fat that just sits there looking ugly, brown fat is like a metabolic furnace that burns calories 24/7 - even while you sleep.
(Aboouf et al., 2023)
Here's the crazy part...
Most people have this fat-burning tissue completely "switched off."
Traditional fat burners actually SUPPRESS this natural fat-burning system by flooding your body with stress hormones.
But what if you could flip
the switch back ON?
What if you could activate your body's natural fat-burning furnace WITHOUT the jitters, anxiety, or crashes?
That's exactly what SHRED does:
How The "Impossible" 30-Minute
Transformation Happens
Within 30 minutes of taking Enhanced Labs Shred, something remarkable happens in your body:
How The "Impossible" 30-Minute Transformation Happens
Within 30 minutes of taking Enhanced Labs Shred, something remarkable happens in your body:
THE 3-SWITCH SYSTEM
Why This Works When Everything Else Fails:
Shred doesn't just dump stimulants into your system and hope for the best.
It targets three specific metabolic switches:
SWITCH #1:
The Heat Switch (Thermogenesis)
CapsiBurn™ — Revolutionary cayenne and tabasco extract in a CLA coating that provides all the fat-burning power of hot peppers WITHOUT destroying your stomach.
CaloriBurn™ — Grains of paradise extract that literally turns white fat into brown fat, creating more metabolic furnaces in your body.
SWITCH #2:
The Energy Switch (Clean Stimulation)
NeuroRush™ — Coffee fruit extract that provides 6+ hours of smooth energy without crashes or anxiety.
250mg Total Caffeine — From multiple sources for sustained energy, not a quick spike and crash.
SWITCH #3:
The Control Switch (Appetite & Cravings)
Naringin — 500mg dose that activates AMPK (your metabolic master switch) and kills cravings.
Green Tea Extract — 150mg EGCG that blocks fat storage and enhances fat oxidation.
All three switches working together =
effortless fat loss that actually feels good.
THE 3-SWITCH SYSTEM
Why This Works When Everything Else Fails:
Shred doesn't just dump stimulants into your system and hope for the best.
It targets three specific metabolic switches:
SWITCH #1:
The Heat Switch (Thermogenesis)
CapsiBurn™ — Revolutionary cayenne and tabasco extract in a CLA coating that provides all the fat-burning power of hot peppers WITHOUT destroying your stomach.
CaloriBurn™ — Grains of paradise extract that literally turns white fat into brown fat, creating more metabolic furnaces in your body.
SWITCH #2:
The Energy Switch
(Clean Stimulation)
NeuroRush™ — Coffee fruit extract that provides 6+ hours of smooth energy without crashes or anxiety.
250mg Total Caffeine — From multiple sources for sustained energy, not a quick spike and crash.
SWITCH #3:
The Control Switch (Appetite & Cravings)
Naringin — 500mg dose that activates AMPK (your metabolic master switch) and kills cravings.
Green Tea Extract — 150mg EGCG that blocks fat storage and enhances fat oxidation.
All three switches working together =
effortless fat loss that actually feels good.
5 Synergistic Systems Working In Perfect Harmony
Unlike other fat burners that just throw random ingredients together,
Enhanced Labs Shred is engineered with 5 specific systems that work together:
SYSTEM #1:
The Thermogenic Activators
CapsiBurn™ (100mg) - Cayenne & tabasco in CLA coating for stomach-friendly heat production
CaloriBurn™ (50mg) - Grains of paradise that converts white fat to metabolically active brown fat
Advantra Z® (100mg) - Clinical-grade synephrine for targeted β-3 receptor activation
This trio creates the "heat switch" effect you'll feel within 20 minutes.
SYSTEM #2:
The Clean Energy Matrix
NeuroRush® (100mg) - Coffee fruit extract for smooth, crash-free mental energy
Caffeine Anhydrous (225mg) - Fast-acting pure caffeine for immediate alertness
Guarana Extract (100mg) - Slow-release caffeine plus natural compounds for sustained energy
Theobromine (100mg) - Smooth, long-lasting stimulation without jitters
250mg total caffeine from 4 sources = 8+ hours of steady energy without crashes.
SYSTEM #3:
The Fat Transport & Oxidation
Acetyl-L-Carnitine (500mg) - Shuttles fatty acids into cellular furnaces for burning
Green Tea Extract (300mg) - 150mg EGCG blocks fat storage and enhances fat burning
Fucoxanthin (2.5mg) - Seaweed extract that increases resting energy expenditure
This system ensures released fat actually gets burned instead of re-stored.
SYSTEM #4:
The Metabolic Optimization
Naringin (500mg) - Citrus flavonoid that activates AMPK (metabolic master switch)
Cinnamon Bark (100mg) - Supports healthy blood sugar and insulin sensitivity
Garcinia Cambogia (250mg) - Blocks carb-to-fat conversion pathways
Optimizes how your body processes and uses nutrients for energy vs storage.
SYSTEM #5:
The Performance
Enhancers
Theacrine (50mg) - Extends energy duration without building tolerance
FitGBB (20mg) - Increases natural carnitine production for enhanced thermogenesis
Amplifies and extends all the other effects for maximum results.
5 Synergistic Systems Working In Perfect Harmony
Unlike other fat burners that just throw random ingredients together,
Enhanced Labs Shred is engineered with 5 specific systems that work together:
SYSTEM #1:
The Thermogenic Activators
CapsiBurn™ (100mg)
Cayenne & tabasco in CLA coating for stomach-friendly heat production
CaloriBurn™ (50mg)
Grains of paradise that converts white fat to metabolically active brown fat
Advantra Z® (100mg)
Clinical-grade synephrine for targeted β-3 receptor activation
This trio creates the "heat switch" effect you'll feel within 20 minutes.
SYSTEM #2:
The Clean Energy Matrix
NeuroRush® (100mg) - Coffee fruit extract for smooth, crash-free mental energy
Caffeine Anhydrous (225mg) - Fast-acting pure caffeine for immediate alertness
Guarana Extract (100mg) - Slow-release caffeine plus natural compounds for sustained energy
Theobromine (100mg) - Smooth, long-lasting stimulation without jitters
250mg total caffeine from 4 sources = 8+ hours of steady energy without crashes.
SYSTEM #3:
The Fat Transport
& Oxidation
Acetyl-L-Carnitine (500mg)
Shuttles fatty acids into cellular furnaces for burning
Green Tea Extract (300mg) 150mg EGCG blocks fat storage and enhances fat burning
Fucoxanthin (2.5mg) Seaweed extract that increases resting energy expenditure
This system ensures released fat actually gets burned instead of re-stored.
SYSTEM #4:
The Metabolic Optimization
Naringin (500mg) - Citrus flavonoid that activates AMPK (metabolic master switch)
Cinnamon Bark (100mg) - Supports healthy blood sugar and insulin sensitivity
Garcinia Cambogia (250mg) - Blocks carb-to-fat conversion pathways
Optimizes how your body processes and uses nutrients for energy vs storage.
SYSTEM #5:
The Performance Enhancers
Theacrine (50mg) - Extends energy duration without building tolerance
FitGBB (20mg) - Increases natural carnitine production for enhanced thermogenesis
Amplifies and extends all the other effects for maximum results.
The Unfair Advantage That Changes Everything
While everyone else is still using 2015 fat burner technology, you'll have access to ingredients that are literally years ahead of anything else available. NeuroRush™ and CapsiBurn™ are exclusive to Aura Scientific.
You cannot get these ingredients anywhere else. Most supplement companies don't even know they exist.
The Unfair Advantage That Changes Everything
While everyone else is still using 2015 fat burner technology, you'll have access to ingredients that are literally years ahead of anything else available.
NeuroRush™ and CapsiBurn™ are exclusive to Aura Scientific.
You cannot get these ingredients anywhere else. Most supplement companies don't even know they exist.
WARNING: THIS ISN'T FOR EVERYONE
Shred works. But it's not magic,
and it's not for everyone:
WARNING: THIS ISN'T FOR EVERYONE
Shred works. But it's not magic, and it's not for everyone:
“SHRED” The Only Fat Burner That Actually
Gets Your Shredded — For Real!
“SHRED” The Only Fat Burner That Actually Gets Your Shredded — For Real!
What Others Are
Saying After Trying Shred:
What Others Are Saying After Trying SHRED:
STILL NOT SURE IF THIS IS FOR YOU?
Frequently Asked Questions
How is this different from other fat burners?
Shred uses next-gen ingredients (NeuroRush™, CapsiBurn™) to avoid jitters, crashes, and gut issues. Its 5-pathway system delivers smooth energy and fat-burning results.
Will this give me jitters or make me crash?
No. The 250mg caffeine blend plus NeuroRush™ delivers clean, lasting energy without spikes or crashes.
Is it okay for sensitive stomachs?
Yes. CapsiBurn™ is CLA-coated to prevent irritation. The formula is gut-friendly and ideal for daily use.
When will I see results?
Most users feel energy and appetite control on Day 1. Fat loss is typically noticeable within 2–4 weeks.
Is it safe for long-term use?
Yes. Ingredients are clinically backed. We recommend cycling off every 8–12 weeks and checking with your doctor.
Can I stack this with other supplements?
Yes—with Enhanced Labs Top T. Do not combine with other stimulant-based products. Space out other caffeine sources by 4–6 hours.
When should I take it?
Take 4 capsules in the morning with water. If you’re stimulant-sensitive, start with 2 capsules to assess tolerance.
Why is it more expensive than other fat burners?
You’re paying for patented ingredients, clinical dosing, and third-party testing—no cheap fillers or underdosed blends.
Will this help if I’ve hit a plateau?
Yes. Shred activates overlooked fat-burning pathways like BAT and AMPK to help break stubborn plateaus.
What if I’m sensitive to caffeine?
Start with a lower dose (2 capsules). NeuroRush™ and Theacrine offer smoother stimulation than pure caffeine.
NOTE: Individual results may vary. Not intended to diagnose, treat, cure, or prevent any disease.
STILL NOT SURE IF THIS IS FOR YOU?
Frequently Asked Questions
How is this different from other fat burners?
Shred uses next-gen ingredients (NeuroRush™, CapsiBurn™) to avoid jitters, crashes, and gut issues. Its 5-pathway system delivers smooth energy and fat-burning results.
Will this give me jitters or make me crash?
No. The 250mg caffeine blend plus NeuroRush™ delivers clean, lasting energy without spikes or crashes.
Is it okay for sensitive stomachs?
Yes. CapsiBurn™ is CLA-coated to prevent irritation. The formula is gut-friendly and ideal for daily use.
When will I see results?
Most users feel energy and appetite control on Day 1. Fat loss is typically noticeable within 2–4 weeks.
Is it safe for long-term use?
Yes. Ingredients are clinically backed. We recommend cycling off every 8–12 weeks and checking with your doctor.
Can I stack this with other supplements?
Yes—with Enhanced Labs Top T. Do not combine with other stimulant-based products. Space out other caffeine sources by 4–6 hours.
When should I take it?
Take 4 capsules in the morning with water. If you’re stimulant-sensitive, start with 2 capsules to assess tolerance.
Why is it more expensive than other fat burners?
You’re paying for patented ingredients, clinical dosing, and third-party testing—no cheap fillers or underdosed blends.
Will this help if I’ve hit a plateau?
Yes. Shred activates overlooked fat-burning pathways like BAT and AMPK to help break stubborn plateaus.
What if I’m sensitive to caffeine?
Start with a lower dose (2 capsules). NeuroRush™ and Theacrine offer smoother stimulation than pure caffeine.
NOTE: Individual results may vary. Not intended to diagnose, treat, cure, or prevent any disease.
Scientific Studies & References
L-Carnitine
Fielding, Roger, et al. "L-Carnitine Supplementation in Recovery after Exercise." Nutrients, vol. 10, no. 3, 13 Mar. 2018, p. 349, doi:10.3390/nu10030349. https://pmc.ncbi.nlm.nih.gov/articles/PMC5872767/
Talenezhad, Nasir, et al. "Effects of L-Carnitine Supplementation on Weight Loss and Body Composition: A Systematic Review and Meta-Analysis of 37 Randomized Controlled Clinical Trials with Dose-Response Analysis." Clinical Nutrition ESPEN, vol. 37, no. 1, June 2020, pp. 9–23, doi:10.1016/j.clnesp.2020.03.008. https://pubmed.ncbi.nlm.nih.gov/32359762/
Vaz, Frédéric M., and Ronald J.A. Wanders. "Carnitine Biosynthesis in Mammals." Biochemical Journal, vol. 361, no. 3, 1 Feb. 2002, p. 417, doi:10.1042/0264-6021:3610417. https://pmc.ncbi.nlm.nih.gov/articles/PMC1222323/
Rebouche, Charles J., et al. "Utilization of Dietary Precursors for Carnitine Synthesis in Human Adults." The Journal of Nutrition, vol. 119, no. 12, 1 Dec. 1989, pp. 1907–1913, doi:10.1093/jn/119.12.1907. https://pubmed.ncbi.nlm.nih.gov/2516120/
Sjakste, Nikolajs, et al. "Endothelium- and Nitric Oxide-Dependent Vasorelaxing Activities of Gamma-Butyrobetaine Esters: Possible Link to the Antiischemic Activities of Mildronate." European Journal of Pharmacology, vol. 495, no. 1, 8 July 2004, pp. 67–73, doi:10.1016/j.ejphar.2004.05.006. https://pubmed.ncbi.nlm.nih.gov/15219822/
Rydzik, Anna M., et al. "Modulating Carnitine Levels by Targeting Its Biosynthesis – Selective Inhibition of γ-Butyrobetaine Hydroxylase." Chem. Sci., vol. 5, no. 5, 2014, pp. 1765–1771, doi:10.1039/c4sc00020j. https://pmc.ncbi.nlm.nih.gov/articles/PMC4678601/
Naringin (Citrus Flavonoid)
Pu, Peng, et al. "Naringin Ameliorates Metabolic Syndrome by Activating AMP-Activated Protein Kinase in Mice Fed a High-Fat Diet." Vol. 518, no. 1, 1 Feb. 2012, pp. 61–70, doi:10.1016/j.abb.2011.11.026. https://pubmed.ncbi.nlm.nih.gov/22198281/
Barajas-Vega, Jessica Lucia, et al. "Naringin Reduces Body Weight, Plasma Lipids and Increases Adiponectin Levels in Patients with Dyslipidemia." International Journal for Vitamin and Nutrition Research, vol. 92, no. 3-4, 9 June 2020, pp. 292–298, doi:10.1024/0300-9831/a000658. https://www.imrpress.com/journal/IJVNR/92/3-4/10.1024/0300-9831/a000658
Jung, Un Ju, et al. "The Hypoglycemic Effects of Hesperidin and Naringin Are Partly Mediated by Hepatic Glucose-Regulating Enzymes in C57BL/KsJ-Db/Db Mice." The Journal of Nutrition, vol. 134, no. 10, 1 Oct. 2004, pp. 2499–2503, doi:10.1093/jn/134.10.2499. https://www.sciencedirect.com/science/article/pii/S0022316623030778
Green Tea Extract & EGCG
Shixian, Q., et al. "Green Tea Extract Thermogenesis-Induced Weight Loss by Epigallocatechin Gallate Inhibition of Catechol-O-Methyltransferase." Journal of Medicinal Food, vol. 9, no. 4, Dec. 2006, pp. 451–458, doi:10.1089/jmf.2006.9.451. https://pubmed.ncbi.nlm.nih.gov/17201629/
Hursel, R., et al. "The Effects of Catechin Rich Teas and Caffeine on Energy Expenditure and Fat Oxidation: A Meta-Analysis." Obesity Reviews, vol. 12, no. 7, 2 Mar. 2011, pp. e573–e581, doi:10.1111/j.1467-789x.2011.00862.x. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1467-789X.2011.00862.x
Asbaghi, Omid, et al. "The Effects of Green Tea Extract Supplementation on Body Composition, Obesity-Related Hormones and Oxidative Stress Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomised Controlled Trials." The British Journal of Nutrition, vol. 131, no. 7, 14 Apr. 2024, pp. 1125–1157, doi:10.1017/S000711452300260X. https://pubmed.ncbi.nlm.nih.gov/38031409/
Hydroxycitric Acid (HCA) / Garcinia
Jena, B S, et al. "Chemistry and Biochemistry of (-)-Hydroxycitric Acid from Garcinia." Journal of Agricultural and Food Chemistry, vol. 50, no. 1, 2002, pp. 10–22, doi:10.1021/jf010753k. https://pubmed.ncbi.nlm.nih.gov/11754536/
Ohia, Sunny E., et al. "Safety and Mechanism of Appetite Suppression by a Novel Hydroxycitric Acid Extract (HCA-SX)." Molecular and Cellular Biochemistry, vol. 238, no. 1-2, 1 Sept. 2002, pp. 89–103, doi:10.1023/a:1019911205672. https://pubmed.ncbi.nlm.nih.gov/12349913/
Cheng, I.-Shiung, et al. "Oral Hydroxycitrate Supplementation Enhances Glycogen Synthesis in Exercised Human Skeletal Muscle." The British Journal of Nutrition, vol. 107, no. 7, 1 Apr. 2012, pp. 1048–1055, doi:10.1017/S0007114511003862. https://pubmed.ncbi.nlm.nih.gov/21824444/
Caffeine
Guest, Nanci S., et al. "International Society of Sports Nutrition Position Stand: Caffeine and Exercise Performance." Journal of the International Society of Sports Nutrition, vol. 18, no. 1, 2 Jan. 2021, doi:10.1186/s12970-020-00383-4. https://pmc.ncbi.nlm.nih.gov/articles/PMC7777221/
Conger, Scott A., et al. "Does Caffeine Increase Fat Metabolism? A Systematic Review and Meta-Analysis." International Journal of Sport Nutrition and Exercise Metabolism, vol. 33, no. 2, 2022, pp. 1–9, doi:10.1123/ijsnem.2022-0131. https://journals.humankinetics.com/view/journals/ijsnem/33/2/article-p112.xml
Spriet, L. L., et al. "Caffeine Ingestion and Muscle Metabolism during Prolonged Exercise in Humans." American Journal of Physiology-Endocrinology and Metabolism, vol. 262, no. 6, 1 June 1992, pp. E891–E898, doi:ajpendo.1992.262.6.e891. https://pubmed.ncbi.nlm.nih.gov/1616022/
Southward, Kyle, et al. "The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta–Analysis." Sports Medicine, vol. 48, no. 8, 6 June 2018, pp. 1913–1928, doi:10.1007/s40279-018-0939-8. https://pubmed.ncbi.nlm.nih.gov/29876876/
Capsaicin & Capsaicinoids
Zsiborás, Csaba, et al. "Capsaicin and Capsiate Could Be Appropriate Agents for Treatment of Obesity: A Meta-Analysis of Human Studies." Critical Reviews in Food Science and Nutrition, vol. 58, no. 9, June 2018, pp. 1419–27. doi:10.1080/10408398.2016.1262324; https://pubmed.ncbi.nlm.nih.gov/28001433/
Inoue, Naohiko, et al. "Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids)." Bioscience, Biotechnology, and Biochemistry, vol. 71, no. 2, 23 Feb. 2007, pp. 380–389, doi:10.1271/bbb.60341. https://pubmed.ncbi.nlm.nih.gov/17284861/
Janssens, Pilou L. H. R., et al. "Acute Effects of Capsaicin on Energy Expenditure and Fat Oxidation in Negative Energy Balance." PLoS ONE, vol. 8, no. 7, July 2013, p. e67786. doi:10.1371/journal.pone.0067786; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699483/
Lejeune, Manuela P. G. M., et al. "Effect of Capsaicin on Substrate Oxidation and Weight Maintenance after Modest Body-Weight Loss in Human Subjects." British Journal of Nutrition, vol. 90, no. 03, Sept. 2003, p. 651, doi:10.1079/bjn2003938. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-capsaicin-on-substrate-oxidation-and-weight-maintenance-after-modest-bodyweight-loss-in-human-subjects/E8121427A21687A67B20E373B787041D
Whiting, S., et al. "Could Capsaicinoids Help to Support Weight Management? A Systematic Review and Meta-Analysis of Energy Intake Data." Appetite, vol. 73, Feb. 2014, pp. 183–88. doi:10.1016/j.appet.2013.11.005; https://pubmed.ncbi.nlm.nih.gov/24246368/
Cinnamon
Anderson, Richard A., et al. "Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity." Journal of Agricultural and Food Chemistry, vol. 52, no. 1, Jan. 2004, pp. 65–70, doi:10.1021/jf034916b. https://pubs.acs.org/doi/10.1021/jf034916b
Hawal Lateef Fateh, and Saman M Amin. "Effects of Cinnamon Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Clinical Nutrition Research, vol. 13, no. 1, 1 Jan. 2024, pp. 74–74, doi:10.7762/cnr.2024.13.1.74. https://pmc.ncbi.nlm.nih.gov/articles/PMC10866674/
Broadhurst, C. Leigh, et al. "Insulin-like Biological Activity of Culinary and Medicinal Plant Aqueous Extracts in Vitro." Journal of Agricultural and Food Chemistry, vol. 48, no. 3, Mar. 2000, pp. 849–852, doi:10.1021/jf9904517. https://pubs.acs.org/doi/10.1021/jf9904517
Guarana
Torres, Elizabeth A. F. S., et al. "Effects of the Consumption of Guarana on Human Health: A Narrative Review." Comprehensive Reviews in Food Science and Food Safety, vol. 21, no. 1, 9 Nov. 2021, pp. 272–295, doi:10.1111/1541-4337.12862. https://pubmed.ncbi.nlm.nih.gov/34755935/
Haskell, C. F., et al. "A Double-Blind, Placebo-Controlled, Multi-Dose Evaluation of the Acute Behavioural Effects of Guaraná in Humans." Journal of Psychopharmacology, vol. 21, no. 1, 13 Mar. 2006, pp. 65–70, doi:10.1177/0269881106063815. https://pubmed.ncbi.nlm.nih.gov/16533867/
Lima, Natália, et al. "Guarana (Paullinia Cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet." Nutrients, vol. 10, no. 2, 31 Jan. 2018, p. 165, doi:10.3390/nu10020165. https://pmc.ncbi.nlm.nih.gov/articles/PMC5852741/
Theobromine (Cocoa)
Jang, Myeong Hwan, et al. "Theobromine, a Methylxanthine in Cocoa Bean, Stimulates Thermogenesis by Inducing White Fat Browning and Activating Brown Adipocytes." Biotechnology and Bioprocess Engineering, vol. 23, no. 6, Nov. 2018, pp. 617–626, doi:10.1007/s12257-018-0434-y. https://link.springer.com/article/10.1007/s12257-018-0434-y
MartÃnez-Pinilla, Eva, et al. "The Relevance of Theobromine for the Beneficial Effects of Cocoa Consumption." Frontiers in Pharmacology, vol. 6, no. 30, 20 Feb. 2015, doi:10.3389/fphar.2015.00030. https://pmc.ncbi.nlm.nih.gov/articles/PMC4335269/
Neufingerl, Nicole, et al. "Effect of Cocoa and Theobromine Consumption on Serum HDL-Cholesterol Concentrations: A Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 97, no. 6, 17 Apr. 2013, pp. 1201–1209, doi:10.3945/ajcn.112.047373. https://www.sciencedirect.com/science/article/pii/S0002916523055387
Camps-Bossacoma, Mariona, et al. "Role of Theobromine in Cocoa's Metabolic Properties in Healthy Rats." Journal of Agricultural and Food Chemistry, vol. 67, no. 13, 11 Mar. 2019, pp. 3605–3614, doi:10.1021/acs.jafc.8b07248. https://pubmed.ncbi.nlm.nih.gov/30855143/
p-Synephrine (Bitter Orange)
Stohs, Sidney J., et al. "A Review of the Receptor-Binding Properties Of p-Synephrine as Related to Its Pharmacological Effects." Oxidative Medicine and Cellular Longevity, vol. 2011, 2011, pp. 1–9, doi:10.1155/2011/482973. https://pmc.ncbi.nlm.nih.gov/articles/PMC3166186/
Stohs, Sidney J., et al. "A Review of the Human Clinical Studies Involving Citrus Aurantium (Bitter Orange) Extract and Its Primary Protoalkaloid P-Synephrine." International Journal of Medical Sciences, vol. 9, no. 7, 2012, pp. 527–538, doi:10.7150/ijms.4446. https://pmc.ncbi.nlm.nih.gov/articles/PMC3444973/
Gutiérrez-Hellín, Jorge, et al. "Acute P-Synephrine Ingestion Increases Whole-Body Fat Oxidation during 1-h of Cycling at Fatmax." European Journal of Nutrition, 5 Nov. 2019, doi:10.1007/s00394-019-02101-6. https://link.springer.com/article/10.1007/s00394-019-02101-6
Gutiérrez-Hellín, Jorge, et al. "Effects of P-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise." Medicine & Science in Sports & Exercise, vol. 50, no. 9, Sept. 2018, pp. 1899–1906, doi:10.1249/mss.0000000000001653. https://journals.lww.com/acsm-msse/fulltext/2018/09000/effects_of_p_synephrine_and_caffeine_ingestion_on.22.aspx
Coffee Berry / Chlorogenic Acid
Reed, Rachelle, et al. "Acute Low and Moderate Doses of a Caffeine-Free Polyphenol-Rich
Coffeeberry Extract Improve Feelings of Alertness and Fatigue Resulting from the Performance of Fatiguing Cognitive Tasks." Journal of Cognitive Enhancement, vol. 3, June 2019. doi:10.1007/s41465-018-0118-8 – https://link.springer.com/article/10.1007/s41465-018-0118-8
Cropley, Vanessa, et al. "Does Coffee Enriched with Chlorogenic Acids Improve Mood and Cognition after Acute Administration in Healthy Elderly? A Pilot Study." Psychopharmacology, vol. 219, no. 3, Feb. 2012, pp. 737–49. doi:10.1007/s00213-011-2395-0; https://pubmed.ncbi.nlm.nih.gov/21773723/
Camfield, David A., et al. "A Randomised Placebo-Controlled Trial to Differentiate the Acute Cognitive and Mood Effects of Chlorogenic Acid from Decaffeinated Coffee." PLoS ONE, vol. 8, no. 12, Dec. 2013, p. e82897. doi:10.1371/journal.pone.0082897. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857311/
Jackson, Philippa A et al. "A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans." Nutrients vol. 12,8 2254. 28 Jul. 2020, doi:10.3390/nu12082254 https://pmc.ncbi.nlm.nih.gov/articles/PMC7468953/
Heimbach, J. T., et al. "Safety Studies on Products from Whole Coffee Fruit." Food and Chemical Toxicology, vol. 48, no. 8, Aug. 2010, pp. 2517–25. doi:10.1016/j.fct.2010.06.025. https://www.sciencedirect.com/science/article/abs/pii/S0278691510003996
Grains of Paradise (Aframomum melegueta)
Riera, CE, et al. "Compounds from Sichuan and Melegueta Peppers Activate, Covalently and Non-Covalently, TRPA1 and TRPV1 Channels." British Journal of Pharmacology, vol. 157, no. 8, Aug. 2009, pp. 1398–1409, doi:10.1111/j.1476-5381.2009.00307.x. https://pmc.ncbi.nlm.nih.gov/articles/PMC2765304/
Sugita, J., Yoneshiro, T., et al; "Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men"; British Journal of Nutrition; (2013) 110(4), pp. 733–738. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-wholebody-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D
Sugita J, Yoneshiro T, et al; "Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans"; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27; https://www.jstage.jst.go.jp/article/jnsv/60/1/60_22/_pdf
Ginger Compounds (6-Paradol, 6-Shogaol)
Wei, Chien-Kei, et al. "6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice." International Journal of Molecular Sciences, vol. 18, no. 1, 17 Jan. 2017, p. 168, doi:10.3390/ijms18010168. https://pmc.ncbi.nlm.nih.gov/articles/PMC5297801/
Theacrine
Zheng, Xin-Qiang, et al. "Theacrine (1,3,7,9-Tetramethyluric Acid) Synthesis in Leaves of a Chinese Tea, Kucha (Camellia Assamica Var. Kucha)." Phytochemistry, vol. 60, no. 2, May 2002, pp. 129–134, doi:10.1016/s0031-9422(02)00086-9. https://www.sciencedirect.com/science/article/abs/pii/S0031942202000869
Taylor, Lem, et al. "Safety of TeaCrine®, a Non-Habituating, Naturally-Occurring Purine Alkaloid over Eight Weeks of Continuous Use." Journal of the International Society of Sports Nutrition, vol. 13, 2016, p. 2, doi:10.1186/s12970-016-0113-3. https://pmc.ncbi.nlm.nih.gov/articles/PMC4711067/
Kuhman, Daniel, et al. "Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women." Nutrients, vol. 7, no. 11, 19 Nov. 2015, pp. 9618–9632, doi:10.3390/nu7115484. https://pmc.ncbi.nlm.nih.gov/articles/PMC4663612/
He, Hui, et al. "Assessment of the Drug-Drug Interaction Potential between Theacrine and Caffeine in Humans." Journal of Caffeine Research, vol. 7, no. 3, 1 Sept. 2017, pp. 95–102, doi:10.1089/jcr.2017.0006. https://pmc.ncbi.nlm.nih.gov/articles/PMC5582588/
Ziegenfuss, Tim N., et al. "A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters." Journal of Dietary Supplements, vol. 14, no. 1, 2 Jan. 2017, pp. 9–24, doi:10.1080/19390211.2016.1178678. https://pubmed.ncbi.nlm.nih.gov/27164220/
Metabolic Syndrome (General)
Choi, Munji, et al. "L-Carnitine's Effect on the Biomarkers of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Nutrients, vol. 12, no. 9, 12 Sept. 2020, p. 2795, doi:10.3390/nu12092795. https://pmc.ncbi.nlm.nih.gov/articles/PMC7551203/
Mielgo-Ayuso, Juan, et al. "Effect of Acute and Chronic Oral L-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review." Nutrients, vol. 13, no. 12, 3 Dec. 2021, p. 4359, doi:10.3390/nu13124359. https://pmc.ncbi.nlm.nih.gov/articles/PMC8704793/
Fucoxanthin (Seaweed Extract)
Maeda, Hayato, et al. "Fucoxanthin from Edible Seaweed, Undaria Pinnatifida, Shows Antiobesity Effect through UCP1 Expression in White Adipose Tissues." Biochemical and Biophysical Research Communications, vol. 332, no. 2, July 2005, pp. 392–397, doi:10.1016/j.bbrc.2005.05.002. https://pubmed.ncbi.nlm.nih.gov/15896707/
Abidov, M., et al. "The Effects of Xanthigen in the Weight Management of Obese Premenopausal Women with Non-Alcoholic Fatty Liver Disease and Normal Liver Fat." Diabetes, Obesity & Metabolism, vol. 12, no. 1, 1 Jan. 2010, pp. 72–81, doi:10.1111/j.1463-1326.2009.01132.x. https://pubmed.ncbi.nlm.nih.gov/19840063/
Zhang, Hui, et al. "Fucoxanthin: A Promising Medicinal and Nutritional Ingredient." Evidence-Based Complementary and Alternative Medicine, vol. 2015, 2015, pp. 1–10, doi:10.1155/2015/723515. https://pmc.ncbi.nlm.nih.gov/articles/PMC4461761/
Scientific Studies & References
L-Carnitine
Fielding, Roger, et al. "L-Carnitine Supplementation in Recovery after Exercise." Nutrients, vol. 10, no. 3, 13 Mar. 2018, p. 349, doi:10.3390/nu10030349. https://pmc.ncbi.nlm.nih.gov/articles/PMC5872767/
Talenezhad, Nasir, et al. "Effects of L-Carnitine Supplementation on Weight Loss and Body Composition: A Systematic Review and Meta-Analysis of 37 Randomized Controlled Clinical Trials with Dose-Response Analysis." Clinical Nutrition ESPEN, vol. 37, no. 1, June 2020, pp. 9–23, doi:10.1016/j.clnesp.2020.03.008. https://pubmed.ncbi.nlm.nih.gov/32359762/
Vaz, Frédéric M., and Ronald J.A. Wanders. "Carnitine Biosynthesis in Mammals." Biochemical Journal, vol. 361, no. 3, 1 Feb. 2002, p. 417, doi:10.1042/0264-6021:3610417. https://pmc.ncbi.nlm.nih.gov/articles/PMC1222323/
Rebouche, Charles J., et al. "Utilization of Dietary Precursors for Carnitine Synthesis in Human Adults." The Journal of Nutrition, vol. 119, no. 12, 1 Dec. 1989, pp. 1907–1913, doi:10.1093/jn/119.12.1907. https://pubmed.ncbi.nlm.nih.gov/2516120/
Sjakste, Nikolajs, et al. "Endothelium- and Nitric Oxide-Dependent Vasorelaxing Activities of Gamma-Butyrobetaine Esters: Possible Link to the Antiischemic Activities of Mildronate." European Journal of Pharmacology, vol. 495, no. 1, 8 July 2004, pp. 67–73, doi:10.1016/j.ejphar.2004.05.006. https://pubmed.ncbi.nlm.nih.gov/15219822/
Rydzik, Anna M., et al. "Modulating Carnitine Levels by Targeting Its Biosynthesis – Selective Inhibition of γ-Butyrobetaine Hydroxylase." Chem. Sci., vol. 5, no. 5, 2014, pp. 1765–1771, doi:10.1039/c4sc00020j. https://pmc.ncbi.nlm.nih.gov/articles/PMC4678601/
Naringin (Citrus Flavonoid)
Pu, Peng, et al. "Naringin Ameliorates Metabolic Syndrome by Activating AMP-Activated Protein Kinase in Mice Fed a High-Fat Diet." Vol. 518, no. 1, 1 Feb. 2012, pp. 61–70, doi:10.1016/j.abb.2011.11.026. https://pubmed.ncbi.nlm.nih.gov/22198281/
Barajas-Vega, Jessica Lucia, et al. "Naringin Reduces Body Weight, Plasma Lipids and Increases Adiponectin Levels in Patients with Dyslipidemia." International Journal for Vitamin and Nutrition Research, vol. 92, no. 3-4, 9 June 2020, pp. 292–298, doi:10.1024/0300-9831/a000658. https://www.imrpress.com/journal/IJVNR/92/3-4/10.1024/0300-9831/a000658
Jung, Un Ju, et al. "The Hypoglycemic Effects of Hesperidin and Naringin Are Partly Mediated by Hepatic Glucose-Regulating Enzymes in C57BL/KsJ-Db/Db Mice." The Journal of Nutrition, vol. 134, no. 10, 1 Oct. 2004, pp. 2499–2503, doi:10.1093/jn/134.10.2499. https://www.sciencedirect.com/science/article/pii/S0022316623030778
Green Tea Extract & EGCG
Shixian, Q., et al. "Green Tea Extract Thermogenesis-Induced Weight Loss by Epigallocatechin Gallate Inhibition of Catechol-O-Methyltransferase." Journal of Medicinal Food, vol. 9, no. 4, Dec. 2006, pp. 451–458, doi:10.1089/jmf.2006.9.451. https://pubmed.ncbi.nlm.nih.gov/17201629/
Hursel, R., et al. "The Effects of Catechin Rich Teas and Caffeine on Energy Expenditure and Fat Oxidation: A Meta-Analysis." Obesity Reviews, vol. 12, no. 7, 2 Mar. 2011, pp. e573–e581, doi:10.1111/j.1467-789x.2011.00862.x. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1467-789X.2011.00862.x
Asbaghi, Omid, et al. "The Effects of Green Tea Extract Supplementation on Body Composition, Obesity-Related Hormones and Oxidative Stress Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomised Controlled Trials." The British Journal of Nutrition, vol. 131, no. 7, 14 Apr. 2024, pp. 1125–1157, doi:10.1017/S000711452300260X. https://pubmed.ncbi.nlm.nih.gov/38031409/
Hydroxycitric Acid (HCA) / Garcinia
Jena, B S, et al. "Chemistry and Biochemistry of (-)-Hydroxycitric Acid from Garcinia." Journal of Agricultural and Food Chemistry, vol. 50, no. 1, 2002, pp. 10–22, doi:10.1021/jf010753k. https://pubmed.ncbi.nlm.nih.gov/11754536/
Ohia, Sunny E., et al. "Safety and Mechanism of Appetite Suppression by a Novel Hydroxycitric Acid Extract (HCA-SX)." Molecular and Cellular Biochemistry, vol. 238, no. 1-2, 1 Sept. 2002, pp. 89–103, doi:10.1023/a:1019911205672. https://pubmed.ncbi.nlm.nih.gov/12349913/
Cheng, I.-Shiung, et al. "Oral Hydroxycitrate Supplementation Enhances Glycogen Synthesis in Exercised Human Skeletal Muscle." The British Journal of Nutrition, vol. 107, no. 7, 1 Apr. 2012, pp. 1048–1055, doi:10.1017/S0007114511003862. https://pubmed.ncbi.nlm.nih.gov/21824444/
Caffeine
Guest, Nanci S., et al. "International Society of Sports Nutrition Position Stand: Caffeine and Exercise Performance." Journal of the International Society of Sports Nutrition, vol. 18, no. 1, 2 Jan. 2021, doi:10.1186/s12970-020-00383-4. https://pmc.ncbi.nlm.nih.gov/articles/PMC7777221/
Conger, Scott A., et al. "Does Caffeine Increase Fat Metabolism? A Systematic Review and Meta-Analysis." International Journal of Sport Nutrition and Exercise Metabolism, vol. 33, no. 2, 2022, pp. 1–9, doi:10.1123/ijsnem.2022-0131. https://journals.humankinetics.com/view/journals/ijsnem/33/2/article-p112.xml
Spriet, L. L., et al. "Caffeine Ingestion and Muscle Metabolism during Prolonged Exercise in Humans." American Journal of Physiology-Endocrinology and Metabolism, vol. 262, no. 6, 1 June 1992, pp. E891–E898, doi:ajpendo.1992.262.6.e891. https://pubmed.ncbi.nlm.nih.gov/1616022/
Southward, Kyle, et al. "The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta–Analysis." Sports Medicine, vol. 48, no. 8, 6 June 2018, pp. 1913–1928, doi:10.1007/s40279-018-0939-8. https://pubmed.ncbi.nlm.nih.gov/29876876/
Capsaicin & Capsaicinoids
Zsiborás, Csaba, et al. "Capsaicin and Capsiate Could Be Appropriate Agents for Treatment of Obesity: A Meta-Analysis of Human Studies." Critical Reviews in Food Science and Nutrition, vol. 58, no. 9, June 2018, pp. 1419–27. doi:10.1080/10408398.2016.1262324; https://pubmed.ncbi.nlm.nih.gov/28001433/
Inoue, Naohiko, et al. "Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids)." Bioscience, Biotechnology, and Biochemistry, vol. 71, no. 2, 23 Feb. 2007, pp. 380–389, doi:10.1271/bbb.60341. https://pubmed.ncbi.nlm.nih.gov/17284861/
Janssens, Pilou L. H. R., et al. "Acute Effects of Capsaicin on Energy Expenditure and Fat Oxidation in Negative Energy Balance." PLoS ONE, vol. 8, no. 7, July 2013, p. e67786. doi:10.1371/journal.pone.0067786; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699483/
Lejeune, Manuela P. G. M., et al. "Effect of Capsaicin on Substrate Oxidation and Weight Maintenance after Modest Body-Weight Loss in Human Subjects." British Journal of Nutrition, vol. 90, no. 03, Sept. 2003, p. 651, doi:10.1079/bjn2003938. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-capsaicin-on-substrate-oxidation-and-weight-maintenance-after-modest-bodyweight-loss-in-human-subjects/E8121427A21687A67B20E373B787041D
Whiting, S., et al. "Could Capsaicinoids Help to Support Weight Management? A Systematic Review and Meta-Analysis of Energy Intake Data." Appetite, vol. 73, Feb. 2014, pp. 183–88. doi:10.1016/j.appet.2013.11.005; https://pubmed.ncbi.nlm.nih.gov/24246368/
Cinnamon
Anderson, Richard A., et al. "Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity." Journal of Agricultural and Food Chemistry, vol. 52, no. 1, Jan. 2004, pp. 65–70, doi:10.1021/jf034916b. https://pubs.acs.org/doi/10.1021/jf034916b
Hawal Lateef Fateh, and Saman M Amin. "Effects of Cinnamon Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Clinical Nutrition Research, vol. 13, no. 1, 1 Jan. 2024, pp. 74–74, doi:10.7762/cnr.2024.13.1.74. https://pmc.ncbi.nlm.nih.gov/articles/PMC10866674/
Broadhurst, C. Leigh, et al. "Insulin-like Biological Activity of Culinary and Medicinal Plant Aqueous Extracts in Vitro." Journal of Agricultural and Food Chemistry, vol. 48, no. 3, Mar. 2000, pp. 849–852, doi:10.1021/jf9904517. https://pubs.acs.org/doi/10.1021/jf9904517
Guarana
Torres, Elizabeth A. F. S., et al. "Effects of the Consumption of Guarana on Human Health: A Narrative Review." Comprehensive Reviews in Food Science and Food Safety, vol. 21, no. 1, 9 Nov. 2021, pp. 272–295, doi:10.1111/1541-4337.12862. https://pubmed.ncbi.nlm.nih.gov/34755935/
Haskell, C. F., et al. "A Double-Blind, Placebo-Controlled, Multi-Dose Evaluation of the Acute Behavioural Effects of Guaraná in Humans." Journal of Psychopharmacology, vol. 21, no. 1, 13 Mar. 2006, pp. 65–70, doi:10.1177/0269881106063815. https://pubmed.ncbi.nlm.nih.gov/16533867/
Lima, Natália, et al. "Guarana (Paullinia Cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet." Nutrients, vol. 10, no. 2, 31 Jan. 2018, p. 165, doi:10.3390/nu10020165. https://pmc.ncbi.nlm.nih.gov/articles/PMC5852741/
Theobromine (Cocoa)
Jang, Myeong Hwan, et al. "Theobromine, a Methylxanthine in Cocoa Bean, Stimulates Thermogenesis by Inducing White Fat Browning and Activating Brown Adipocytes." Biotechnology and Bioprocess Engineering, vol. 23, no. 6, Nov. 2018, pp. 617–626, doi:10.1007/s12257-018-0434-y. https://link.springer.com/article/10.1007/s12257-018-0434-y
MartÃnez-Pinilla, Eva, et al. "The Relevance of Theobromine for the Beneficial Effects of Cocoa Consumption." Frontiers in Pharmacology, vol. 6, no. 30, 20 Feb. 2015, doi:10.3389/fphar.2015.00030. https://pmc.ncbi.nlm.nih.gov/articles/PMC4335269/
Neufingerl, Nicole, et al. "Effect of Cocoa and Theobromine Consumption on Serum HDL-Cholesterol Concentrations: A Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 97, no. 6, 17 Apr. 2013, pp. 1201–1209, doi:10.3945/ajcn.112.047373. https://www.sciencedirect.com/science/article/pii/S0002916523055387
Camps-Bossacoma, Mariona, et al. "Role of Theobromine in Cocoa's Metabolic Properties in Healthy Rats." Journal of Agricultural and Food Chemistry, vol. 67, no. 13, 11 Mar. 2019, pp. 3605–3614, doi:10.1021/acs.jafc.8b07248. https://pubmed.ncbi.nlm.nih.gov/30855143/
p-Synephrine (Bitter Orange)
Stohs, Sidney J., et al. "A Review of the Receptor-Binding Properties Of p-Synephrine as Related to Its Pharmacological Effects." Oxidative Medicine and Cellular Longevity, vol. 2011, 2011, pp. 1–9, doi:10.1155/2011/482973. https://pmc.ncbi.nlm.nih.gov/articles/PMC3166186/
Stohs, Sidney J., et al. "A Review of the Human Clinical Studies Involving Citrus Aurantium (Bitter Orange) Extract and Its Primary Protoalkaloid P-Synephrine." International Journal of Medical Sciences, vol. 9, no. 7, 2012, pp. 527–538, doi:10.7150/ijms.4446. https://pmc.ncbi.nlm.nih.gov/articles/PMC3444973/
Gutiérrez-Hellín, Jorge, et al. "Acute P-Synephrine Ingestion Increases Whole-Body Fat Oxidation during 1-h of Cycling at Fatmax." European Journal of Nutrition, 5 Nov. 2019, doi:10.1007/s00394-019-02101-6. https://link.springer.com/article/10.1007/s00394-019-02101-6
Gutiérrez-Hellín, Jorge, et al. "Effects of P-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise." Medicine & Science in Sports & Exercise, vol. 50, no. 9, Sept. 2018, pp. 1899–1906, doi:10.1249/mss.0000000000001653. https://journals.lww.com/acsm-msse/fulltext/2018/09000/effects_of_p_synephrine_and_caffeine_ingestion_on.22.aspx
Coffee Berry / Chlorogenic Acid
Reed, Rachelle, et al. "Acute Low and Moderate Doses of a Caffeine-Free Polyphenol-Rich
Coffeeberry Extract Improve Feelings of Alertness and Fatigue Resulting from the Performance of Fatiguing Cognitive Tasks." Journal of Cognitive Enhancement, vol. 3, June 2019. doi:10.1007/s41465-018-0118-8 – https://link.springer.com/article/10.1007/s41465-018-0118-8
Cropley, Vanessa, et al. "Does Coffee Enriched with Chlorogenic Acids Improve Mood and Cognition after Acute Administration in Healthy Elderly? A Pilot Study." Psychopharmacology, vol. 219, no. 3, Feb. 2012, pp. 737–49. doi:10.1007/s00213-011-2395-0; https://pubmed.ncbi.nlm.nih.gov/21773723/
Camfield, David A., et al. "A Randomised Placebo-Controlled Trial to Differentiate the Acute Cognitive and Mood Effects of Chlorogenic Acid from Decaffeinated Coffee." PLoS ONE, vol. 8, no. 12, Dec. 2013, p. e82897. doi:10.1371/journal.pone.0082897. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857311/
Jackson, Philippa A et al. "A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans." Nutrients vol. 12,8 2254. 28 Jul. 2020, doi:10.3390/nu12082254 https://pmc.ncbi.nlm.nih.gov/articles/PMC7468953/
Heimbach, J. T., et al. "Safety Studies on Products from Whole Coffee Fruit." Food and Chemical Toxicology, vol. 48, no. 8, Aug. 2010, pp. 2517–25. doi:10.1016/j.fct.2010.06.025. https://www.sciencedirect.com/science/article/abs/pii/S0278691510003996
Grains of Paradise (Aframomum melegueta)
Riera, CE, et al. "Compounds from Sichuan and Melegueta Peppers Activate, Covalently and Non-Covalently, TRPA1 and TRPV1 Channels." British Journal of Pharmacology, vol. 157, no. 8, Aug. 2009, pp. 1398–1409, doi:10.1111/j.1476-5381.2009.00307.x. https://pmc.ncbi.nlm.nih.gov/articles/PMC2765304/
Sugita, J., Yoneshiro, T., et al; "Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men"; British Journal of Nutrition; (2013) 110(4), pp. 733–738. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-wholebody-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D
Sugita J, Yoneshiro T, et al; "Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans"; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27; https://www.jstage.jst.go.jp/article/jnsv/60/1/60_22/_pdf
Ginger Compounds (6-Paradol, 6-Shogaol)
Wei, Chien-Kei, et al. "6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice." International Journal of Molecular Sciences, vol. 18, no. 1, 17 Jan. 2017, p. 168, doi:10.3390/ijms18010168. https://pmc.ncbi.nlm.nih.gov/articles/PMC5297801/
Theacrine
Zheng, Xin-Qiang, et al. "Theacrine (1,3,7,9-Tetramethyluric Acid) Synthesis in Leaves of a Chinese Tea, Kucha (Camellia Assamica Var. Kucha)." Phytochemistry, vol. 60, no. 2, May 2002, pp. 129–134, doi:10.1016/s0031-9422(02)00086-9. https://www.sciencedirect.com/science/article/abs/pii/S0031942202000869
Taylor, Lem, et al. "Safety of TeaCrine®, a Non-Habituating, Naturally-Occurring Purine Alkaloid over Eight Weeks of Continuous Use." Journal of the International Society of Sports Nutrition, vol. 13, 2016, p. 2, doi:10.1186/s12970-016-0113-3. https://pmc.ncbi.nlm.nih.gov/articles/PMC4711067/
Kuhman, Daniel, et al. "Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women." Nutrients, vol. 7, no. 11, 19 Nov. 2015, pp. 9618–9632, doi:10.3390/nu7115484. https://pmc.ncbi.nlm.nih.gov/articles/PMC4663612/
He, Hui, et al. "Assessment of the Drug-Drug Interaction Potential between Theacrine and Caffeine in Humans." Journal of Caffeine Research, vol. 7, no. 3, 1 Sept. 2017, pp. 95–102, doi:10.1089/jcr.2017.0006. https://pmc.ncbi.nlm.nih.gov/articles/PMC5582588/
Ziegenfuss, Tim N., et al. "A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters." Journal of Dietary Supplements, vol. 14, no. 1, 2 Jan. 2017, pp. 9–24, doi:10.1080/19390211.2016.1178678. https://pubmed.ncbi.nlm.nih.gov/27164220/
Metabolic Syndrome (General)
Choi, Munji, et al. "L-Carnitine's Effect on the Biomarkers of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Nutrients, vol. 12, no. 9, 12 Sept. 2020, p. 2795, doi:10.3390/nu12092795. https://pmc.ncbi.nlm.nih.gov/articles/PMC7551203/
Mielgo-Ayuso, Juan, et al. "Effect of Acute and Chronic Oral L-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review." Nutrients, vol. 13, no. 12, 3 Dec. 2021, p. 4359, doi:10.3390/nu13124359. https://pmc.ncbi.nlm.nih.gov/articles/PMC8704793/
Fucoxanthin (Seaweed Extract)
Maeda, Hayato, et al. "Fucoxanthin from Edible Seaweed, Undaria Pinnatifida, Shows Antiobesity Effect through UCP1 Expression in White Adipose Tissues." Biochemical and Biophysical Research Communications, vol. 332, no. 2, July 2005, pp. 392–397, doi:10.1016/j.bbrc.2005.05.002. https://pubmed.ncbi.nlm.nih.gov/15896707/
Abidov, M., et al. "The Effects of Xanthigen in the Weight Management of Obese Premenopausal Women with Non-Alcoholic Fatty Liver Disease and Normal Liver Fat." Diabetes, Obesity & Metabolism, vol. 12, no. 1, 1 Jan. 2010, pp. 72–81, doi:10.1111/j.1463-1326.2009.01132.x. https://pubmed.ncbi.nlm.nih.gov/19840063/
Zhang, Hui, et al. "Fucoxanthin: A Promising Medicinal and Nutritional Ingredient." Evidence-Based Complementary and Alternative Medicine, vol. 2015, 2015, pp. 1–10, doi:10.1155/2015/723515. https://pmc.ncbi.nlm.nih.gov/articles/PMC4461761/
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If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using our products.
Copyright © 2025 Enhanced Labs |
All Rights Reserved
Statements on this website have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using our products.