THE RESULT MIGHT SHOCK YOU:
What Happens When You
Naturally Boost Test to Peak Levels?
Designed for men who feel “off” but can’t explain why —Top T helps
reset your body’s natural testosterone, giving you back strength, mood, and motivation.
THE RESULT MIGHT SHOCK YOU:
What Happens When You Naturally Boost Test to Peak Levels?
Designed for men who feel “off” but can’t explain why —Top T helps reset your body’s natural testosterone, giving you back strength, mood, and motivation.
Tired for no reason?
Less drive in the gym — and in the bedroom. Mood’s off.
Focus is shot.
And you can’t even explain why.
It’s not “just stress.”
It’s not “getting older.”
It’s likely low testosterone — and Top T helps you fix it fast, naturally, and without hormonal therapy.
Tired for no reason?
Less drive in the gym — and in the bedroom.
Mood’s off.
Focus is shot.
And you can’t even explain why.
It’s not “just stress.”
It’s not “getting older.”
It’s likely low testosterone — and Top T helps you fix it fast, naturally, and without hormonal therapy.
AND HERE'S THE TRUTH
Modern Life Is Making You Weaker — And You Don’t Even See It Happening.
You wake up tired. You don’t feel sharp. You force yourself through the day, then crash at night — wired but exhausted.
And that spark you used to have?
It’s gone.
Not burned out. Just… flat.
This isn’t just stress, poor sleep, or “getting older.”
It’s what happens when your testosterone levels quietly crash...
And your brain rewires itself to crave quick dopamine hits instead of real, lasting wins.
The Cheap Dopamine Trap
- Reaching for caffeine instead of attacking the gym
- Endless scrolling, no ambition to create
- Bingeing shows, skipping workouts
- Junk food > real meals
- No passion in the sheets
- Mood swings outta nowhere
- Social battery = dead by 6 PM
- You don’t chase goals. You chase comfort.
This isn’t your fault... but it is your responsibility to fix.
Top T was built for men who realized the spark was fading and decided not to just “accept it.”
AND HERE'S THE TRUTH
Modern Life Is Making You Weaker —
And You Don’t Even See It Happening.
You wake up tired. You don’t feel sharp.
You force yourself through the day, then crash at night — wired but exhausted.
And that spark you used to have?
It’s gone.
Not burned out. Just… flat.
This isn’t just stress, poor sleep, or “getting older.”
It’s what happens when your testosterone levels quietly crash...
And your brain rewires itself to crave quick dopamine hits instead of real, lasting wins.
The Cheap Dopamine Trap
- Reaching for caffeine instead of attacking the gym
- Endless scrolling, no ambition to create
- Bingeing shows, skipping workouts
- Junk food > real meals
- No passion in the sheets
- Mood swings outta nowhere
- Social battery = dead by 6 PM
- You don’t chase goals. You chase comfort.
This isn’t your fault...
but it is your responsibility to fix.
Top T was built for men who realized the spark was fading and decided not to just “accept it.”
Introducing Top T — Your Comeback Formula
When your drive, strength, and energy feel off… this is how you fix it.
Naturally. Permanently.
Top T is more than just a testosterone booster —
It’s a full-spectrum hormone optimizer built for men who are done feeling average.
No needles. No BS.
Just ingredients that work — in the right dose, backed by science, and designed to help you feel like you again.
WHAT'S INSIDE:
7 Powerhouse Ingredients That Make Top T Work
These aren’t your average test booster ingredients. Each one is clinically chosen to reignite your body’s natural testosterone engine — helping you feel stronger, sharper, and more alive every single day.
SHILAJIT:
The Ancient Testosterone Secret: A legendary Ayurvedic mineral-rich resin shown to help boost testosterone levels, increase energy at the cellular level, and enhance male vitality.
BONUS: Supports ATP production, recovery, and blood flow.
FADOGIA AGRESTIS:
Natural LH Stimulator: Helps activate Luteinizing Hormone (LH), which signals your body to produce more natural testosterone.
BONUS: Enhances libido, mood, and motivation without hormonal shutdown.
PROTOTEST™: (Protodioscin)
Libido + Strength Enhancer: Extracted from Tribulus terrestris, this bioactive boosts libido, supports testosterone production, and improves athletic performance.
BONUS: Helps drive faster recovery and strength gains.
ENDOFLO™:
The Hormone Balancer: Our trademark blend that modulates estrogen levels while supporting healthy hormone balance and promote overall vitality.
BONUS: Supports hormonal clarity and reduces cortisol.
PREGNENOLONE:
Mood & Mental Edge: Known as the “mother hormone,” this precursor supports mental sharpness, memory, and hormone synthesis.
BONUS: Helps fight brain fog and mood instability caused by low T.
MICRONUTRIENT MATRIX:
The Recovery Foundation: Clinically dosed Boron, Zinc, and Vitamin D3 to restore deficiencies, support immunity, and improve total hormone balance.
BONUS: Fuels sleep, strength, and overall resilience.
While most boosters throw random herbs in a bottle and hope it sticks...
Every ingredient in Top T serves a specific, science-backed purpose.
Introducing Top T — Your Comeback Formula
When your drive, strength, and energy feel off… this is how you fix it.
Naturally. Permanently.
Top T is more than just a testosterone booster —
It’s a full-spectrum hormone optimizer built for men who are done feeling average.
No needles. No BS.
Just ingredients that work — in the right dose, backed by science, and designed to help you feel like you again.
WHAT'S INSIDE:
7 Powerhouse Ingredients That Make Top T Work
These aren’t your average test booster ingredients. Each one is clinically chosen to reignite your body’s natural testosterone engine — helping you feel stronger, sharper, and more alive every single day.
SHILAJIT:
The Ancient Testosterone Secret: A legendary Ayurvedic mineral-rich resin shown to help boost testosterone levels, increase energy at the cellular level, and enhance male vitality.
BONUS: Supports ATP production, recovery, and blood flow.
FADOGIA AGRESTIS:
Natural LH Stimulator: Helps activate Luteinizing Hormone (LH), which signals your body to produce more natural testosterone.
BONUS: Enhances libido, mood, and motivation without hormonal shutdown.
PROTOTEST™: (Protodioscin)
Libido + Strength Enhancer: Extracted from Tribulus terrestris, this bioactive boosts libido, supports testosterone production, and improves athletic performance.
BONUS: Helps drive faster recovery and strength gains.
ENDOFLO™:
The Hormone Balancer: Our trademark blend that modulates estrogen levels while supporting healthy hormone balance and promote overall vitality
BONUS: Supports hormonal clarity and reduces cortisol.
PREGNENOLONE:
Mood & Mental Edge: Known as the “mother hormone,” this precursor supports mental sharpness, memory, and hormone synthesis.
BONUS: Helps fight brain fog and mood instability caused by low T.
MICRONUTRIENT MATRIX:
The Recovery Foundation: Clinically dosed Boron, Zinc, and Vitamin D3 to restore deficiencies, support immunity, and improve total hormone balance.
BONUS: Fuels sleep, strength, and overall resilience.
While most boosters throw random herbs in a bottle and hope it sticks...
Every ingredient in Top T serves a specific, science-backed purpose.
AND THAT'S WHY WE CREATED TOP T
Most “Solutions” Are Just Expensive, Ineffective, or Straight-Up Risky.
Chances are, you’ve already tried something. TRT clinics.
Gimmicky boosters. Overhyped powders. “Natural hacks.”
Either they didn’t work, came with baggage — or you bailed before they got scary.
This isn’t another hype pill...
Top T was engineered for real men with real lives — no gimmicks, no grey-area ingredients, and no synthetic hormones.
Just a formula that works with your body, not against it.
AND THAT'S WHY WE CREATED TOP T
Most “Solutions” Are Just Expensive,
Ineffective, or Straight-Up Risky.
Chances are, you’ve already tried something. TRT clinics. Gimmicky boosters. Overhyped powders. “Natural hacks.”
Either they didn’t work, came with baggage — or you bailed before they got scary.
This isn’t another hype pill...
Top T was engineered for real men with real lives — no gimmicks, no grey-area ingredients, and no synthetic hormones. Just a formula that works with your body, not against it.
The Only Test Support Formula That Hits All 3 Pathways That Actually Matter
Most testosterone boosters only focus on one thing (and usually do it poorly).
Top T is different... it’s built to attack the problem from all angles— so you feel results faster and they actually stick.
You’ve seen the options...
Most guys get stuck trying cheap fixes or end up locked into costly hormone therapy.
Top T gives you the results you want — without the BS, risks, guesswork, or regret.
The Only Test Support Formula That
Hits All 3 Pathways That Actually Matter
Most testosterone boosters only focus on one thing (and usually do it poorly).
Top T is different... it’s built to attack the problem from all angles— so you feel results faster and they actually stick.
You’ve seen the options...
Most guys get stuck trying cheap fixes or end up locked into costly hormone therapy.
Top T gives you the results you want — without the BS, risks, guesswork, or regret.
Start Your Comeback. Choose Your Stack.
This isn’t about Top T bottles. It’s about building a version of you that
wakes up driven, dominates the day, and feels alive again.
Start Your Comeback. Choose Your Stack.
This isn’t about Top T bottles. It’s about building a version of you that
wakes up driven, dominates the day, and feels alive again.
What Other Men Are Saying After Trying Top T:
What Other Men Are Saying After Trying Top T:
What Other Men Are
Saying After Trying Top T:
You’re One Decision Away From Feeling Like Yourself Again.
Every day you delay fixing your testosterone isn’t just costing you energy
— it’s costing you confidence, strength, and drive.
Top T was built for men like you to take back control naturally.
And if it doesn’t work? You’re covered by our 60-Day Money-Back Guarantee.
Try it. Feel it. Or don’t pay.
You’re One Decision Away From Feeling Like Yourself Again.
Every day you delay fixing your testosterone isn’t just costing you energy
— it’s costing you confidence, strength, and drive.
Top T was built for men like you to take back control naturally.
And if it doesn’t work? You’re covered by our 60-Day Money-Back Guarantee.
Try it. Feel it. Or don’t pay.
STILL NOT SURE IF THIS IS FOR YOU?
Frequently Asked Questions
I’ve tried other test boosters. Will this actually work?
Top T was designed after studying where most boosters fail — underdosing, weak blends, no hormonal support. We fixed that. Real ingredients, full clinical doses, no fluff. Most users feel a difference in energy, mood, and performance within 2–3 weeks.
Is this safe? Any side effects?
Top T uses only well-researched, naturally occurring ingredients. No stimulants, no synthetic hormones, no sketchy compounds. It’s designed to support your body — not override it.
Do I have to take this forever?
Nope.Top T supports your natural testosterone production, not replace it. You can cycle it, stack it, or pause as needed — most guys stay on it because they feel damn good.
What’s the dose / how do I take it?
Just take 4 capsules daily, preferably with a meal. Morning or pre-workout works great.
Stay consistent for best results.
What if it doesn’t work for me?
No stress. You’ve got a 60-Day Money-Back Guarantee — try it risk-free. If it doesn’t work, you get your money back. No questions asked.
Scientific Studies & References
Testosterone & Hormone Optimization
Tribulus Terrestris
Jones, Hugh. "Testosterone for the Aging Male; Current Evidence and Recommended Practice." Clinical Interventions in Aging, vol. Volume 3, no. 1, Mar. 2008, pp. 25–44, doi:10.2147/cia.s190. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544367/
Gauthaman, Kalamegam, et al. "Sexual Effects of Puncturevine (Tribulus Terrestris) Extract (Protodioscin): An Evaluation Using a Rat Model." The Journal of Alternative and Complementary Medicine, vol. 9, no. 2, Apr. 2003, pp. 257–265, doi:10.1089/10755530360623374. https://pubmed.ncbi.nlm.nih.gov/12804079/
Adaikan, P. G., et al. "History of Herbal Medicines with an Insight on the Pharmacological Properties Of Tribulus Terrestris." The Aging Male, vol. 4, no. 3, Jan. 2001, pp. 163–169, https://www.tandfonline.com/doi/abs/10.1080/tam.4.3.163.169
Ștefănescu, Ruxandra, et al. "A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus Terrestris L." Biomolecules, vol. 10, no. 5, 12 May 2020, p. 752, doi:10.3390/biom10050752. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277861/
Dinchev, Dragomir, et al. "Distribution of Steroidal Saponins in Tribulus Terrestris from Different Geographical Regions." Phytochemistry, vol. 69, no. 1, Jan. 2008, pp. 176–186, doi:10.1016/j.phytochem.2007.07.003. https://www.sciencedirect.com/science/article/abs/pii/S0031942207004657
Adimoelja, A., and P. Adaikan. "Protodioscin from Herbal Plant Tribulus Terrestris L Improves the Male Sexual Functions, Probably via DHEA." Semantic Scholar, 1997; https://www.semanticscholar.org/paper/Protodioscin-from-herbal-plant-Tribulus-terrestris-Adimoelja-Adaikan/1355db896a86c6cff7b69e057b48bd5cea96f241
Gauthaman, Kalamegam, and Adaikan P Ganesan. "The Hormonal Effects of Tribulus Terrestris and Its Role in the Management of Male Erectile Dysfunction–an Evaluation Using Primates, Rabbit and Rat." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 15, no. 1-2, 2008, pp. 44–54, https://www.ncbi.nlm.nih.gov/pubmed/18068966/
Fadogia Agrestis
Raman, Vijayasankar, et al. "Microscopic Characterization and HPTLC of the Leaves, Stems and Roots of Fadogia Agrestis – an African Folk Medicinal Plant." Revista Brasileira de Farmacognosia, vol. 28, 2018, pp. 631–639, https://doi.org/10.1016/j.bjp.2018.07.006
Yakubu, M T et al. "Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats." Asian journal of andrology vol. 7,4 (2005): 399-404. doi:10.1111/j.1745-7262.2005.00052.x https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1745-7262.2005.00052.x
Yakubu, Musa Toyin et al. "Effects of oral administration of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem on some testicular function indices of male rats." Journal of ethnopharmacology vol. 115,2 (2008): 288-92. doi:10.1016/j.jep.2007.10.004. https://www.sciencedirect.com/science/article/abs/pii/S0378874107005296
Tongkat Ali (Eurycoma longifolia)
Leitão, Alice Erwig et al. "A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM)." Maturitas vol. 145 (2021): 78-85; https://pubmed.ncbi.nlm.nih.gov/33541567/
Kotirum, Surachai, et al. "Efficacy of Tongkat Ali (Eurycoma Longifolia) on Erectile Function Improvement: Systematic Review and Meta-Analysis of Randomized Controlled Trials." Complementary Therapies in Medicine, vol. 23, no. 5, Oct. 2015, pp. 693–698, doi:10.1016/j.ctim.2015.07.009. https://pubmed.ncbi.nlm.nih.gov/26365449/
Leisegang, Kristian et al. "Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials." Medicina (Kaunas, Lithuania) vol. 58,8 1047. 4 Aug. 2022, doi:10.3390/medicina58081047. https://www.mdpi.com/1648-9144/58/8/1047
Talbott, Shawn M, et al. "Effect of Tongkat Ali on Stress Hormones and Psychological Mood State in Moderately Stressed Subjects." Journal of the International Society of Sports Nutrition, vol. 10, 26 May 2013, p. 28, doi:10.1186/1550-2783-10-28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669033/
Hamzah, Sareena and Yusof, Ashril. "The ergogenic effects of Tongkat ali (Eurycoma longifolia): A pilot study." British J Sports Med. 2003, vol. 37: 464-470. https://www.researchgate.net/publication/341998425_The_Ergogenic_Effect_of_Eurycoma_longifolia_Jack_A_Pilot_Study
Adaptogenic & Performance Herbs
Ashwagandha (Withania somnifera)
Chandrasekhar, K, et al; "A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults."; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; July 2012; https://www.ncbi.nlm.nih.gov/pubmed/23439798
Ahmad, Mohammad Kaleem, et al. "Withania Somnifera Improves Semen Quality by Regulating Reproductive Hormone Levels and Oxidative Stress in Seminal Plasma of Infertile Males." Fertility and Sterility, vol. 94, no. 3, 2010, pp. 989–96, doi:10.1016/j.fertnstert.2009.04.046. https://pubmed.ncbi.nlm.nih.gov/19501822/
Sandhu, Jaspal Singh, et al. "Effects of Withania Somnifera (Ashwagandha) and Terminalia Arjuna (Arjuna) on Physical Performance and Cardiorespiratory Endurance in Healthy Young Adults." International Journal of Ayurveda Research, vol. 1, no. 3, 2010, pp. 144–9, doi:10.4103/0974-7788.72485. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996571/
Maca (Lepidium meyenii)
Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska L; "Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content."; Menopause; 2008; 15(6); 1157–1162; https://pubmed.ncbi.nlm.nih.gov/18784609
Melnikovova, Ingrid, et al. "Effect OfLepidium MeyeniiWalp. On Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study." Evidence-Based Complementary and Alternative Medicine, vol. 2015, 2015, pp. 1–6, doi:10.1155/2015/324369. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569766/
Lee, Myeong Soo, et al. "The Use of Maca (Lepidium Meyenii) to Improve Semen Quality: A Systematic Review." Maturitas, vol. 92, 1 Oct. 2016, pp. 64–69, doi:10.1016/j.maturitas.2016.07.013. https://pubmed.ncbi.nlm.nih.gov/27621241/
Choi, E., et al; "Supplementation of Standardized Lipid-Soluble Extract from Maca (Lepidium Meyenii) Increases Swimming Endurance Capacity in Rats.";Journal of Functional Foods; Elsevier; 4 Apr. 2012; https://www.sciencedirect.com/science/article/pii/S1756464612000436
Jiannine, LM and Antonio, J.; "The Effects of Lepidium Meyenii on Grip Strength, Fatigue, and Sexual Behavior."; Journal of Exercise and Nutrition; 2019; 2(1); https://www.journalofexerciseandnutrition.com/ManuscriptUploadsPDF/72.pdf
Shilajit
Pandit, S., et al. "Clinical Evaluation of Purified Shilajit on Testosterone Levels in Healthy Volunteers." Andrologia, vol. 48, no. 5, 22 Sept. 2015, pp. 570–575, doi:10.1111/and.12482. https://onlinelibrary.wiley.com/doi/10.1111/and.12482
Safed Musli (Chlorophytum borivilianum)
Rath, SudiptaKumar, and AsitKumar Panja. "Clinical Evaluation of Root Tubers of Shweta Musali (Chlorophytum Borivilianum L.) and Its Effect on Semen and Testosterone." AYU (an International Quarterly Journal of Research in Ayurveda), vol. 34, no. 3, 2013, p. 273, doi:10.4103/0974-8520.123118. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902593/
Khanam, Zakia, et al. "Safed Musli (Chlorophytum Borivilianum): A Review of Its Botany, Ethnopharmacology and Phytochemistry." Journal of Ethnopharmacology, vol. 150, no. 2, Nov. 2013, pp. 421–441, doi:10.1016/j.jep.2013.08.064. https://pubmed.ncbi.nlm.nih.gov/24045177/
Vascular Health & Circulation
Horny Goat Weed (Epimedium/Icariin)
Chau, Yasmin, et al. "Exploration of Icariin Analog Structure Space Reveals Key Features Driving Potent Inhibition of Human Phosphodiesterase-5." PLOS ONE, vol. 14, no. 9, 20 Sept. 2019, p. e0222803, doi:10.1371/journal.pone.0222803. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754136/
Jin, Feng, et al. "Icariin, a Phoshphodiesterase-5 Inhibitor, Improves Learning and Memory in APP/PS1 Transgenic Mice by Stimulation of NO/CGMP Signalling." The International Journal of Neuropsychopharmacology, vol. 17, no. 06, 11 Feb. 2014, pp. 871–881, doi:10.1017/s1461145713001533. https://pubmed.ncbi.nlm.nih.gov/24513083/
Fang, Jian, and Yongjun Zhang. "Icariin, an Anti-Atherosclerotic Drug from Chinese Medicinal Herb Horny Goat Weed." Frontiers in Pharmacology, vol. 8, 12 Oct. 2017, doi:10.3389/fphar.2017.00734. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644024/
Xin, Z. C., et al. "Effects of Icariin on CGMP-Specific PDE5 and CAMP-Specific PDE4 Activities." Asian Journal of Andrology, vol. 5, no. 1, 1 Mar. 2003, pp. 15–18; https://pubmed.ncbi.nlm.nih.gov/12646997/
Zhang, Zhen-Bao, and Qing-Tao Yang. "The Testosterone Mimetic Properties of Icariin." Asian Journal of Andrology, vol. 8, no. 5, 1 Sept. 2006, pp. 601–605, doi:10.1111/j.1745-7262.2006.00197.x. https://pubmed.ncbi.nlm.nih.gov/16751992/
Wang, Pengzhen, et al. "Icariin Activates Far Upstream Element Binding Protein 1 to Regulate Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α Signaling and Benefits Chondrocytes." PeerJ, vol. 11, 22 Aug. 2023, pp. e15917–e15917, doi:10.7717/peerj.15917. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452614/
Lin, Yi-An et al. "Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy." Scientific reports vol. 11,1 10790. 24 May. 2021, doi:10.1038/s41598-021-89039-0 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144409/
Chen, Sui-Qing et al. "Icariin induces irisin/FNDC5 expression in C2C12 cells via the AMPK pathway." Biomedicine & pharmacotherapy vol. 115 (2019): 108930. doi:10.1016/j.biopha.2019.108930 https://www.sciencedirect.com/science/article/pii/S0753332219306973
Ginkgo Biloba
Mahadevan, S, and Y Park. "Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses." Journal of food science vol. 73,1 (2008): R14-9. doi:10.1111/j.1750-3841.2007.00597.x https://ift.onlinelibrary.wiley.com/doi/10.1111/j.1750-3841.2007.00597.x
Mehlsen, J., et al. "Effects of a Ginkgo Biloba Extract on Forearm Haemodynamics in Healthy Volunteers." Clinical Physiology and Functional Imaging, vol. 22, no. 6, Nov. 2002, pp. 375–78. doi:10.1046/j.1475-097x.2002.00445.x; https://pubmed.ncbi.nlm.nih.gov/12464140/
Silva, Henrique, and Filipe Gazalho Martins. "Cardiovascular Activity of Ginkgo Biloba—An Insight from Healthy Subjects." Biology, vol. 12, no. 1, Dec. 2022, p. 15. doi:10.3390/biology12010015; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855530/
Mashayekh, Ameneh et al. "Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study." Neuroradiology vol. 53,3 (2011): 185-91. doi:10.1007/s00234-010-0790-6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163160/
Eisvand, Farhad, et al. "The Effects of Ginkgo Biloba on Metabolic Syndrome: A Review." Phytotherapy Research, vol. 34, no. 8, Aug. 2020, pp. 1798–811. doi:10.1002/ptr.6646; https://www.ncbi.nlm.nih.gov/pubmed/32097990
Black Ginger (Kaempferia parviflora)
Lee, Sunkyu, et al. "Standardized Kaempferia Parviflora Wall. Ex Baker (Zingiberaceae) Extract Inhibits Fat Accumulation and Muscle Atrophy in Ob/Ob Mice." Evidence-Based Complementary and Alternative Medicine, vol. 2018, May 2018, p. 8161042. doi:10.1155/2018/8161042; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994587/
Toda, Kazuya, et al. "Black Ginger Extract Increases Physical Fitness Performance and Muscular Endurance by Improving Inflammation and Energy Metabolism." Heliyon, vol. 2, no. 5, May 2016, p. e00115. doi:10.1016/j.heliyon.2016.e00115. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946221/
Huang, Jiapeng, et al. "Black Ginger (Kaempferia Parviflora) Extract Enhances Endurance Capacity by Improving Energy Metabolism and Substrate Utilization in Mice." Nutrients, vol. 14, no. 18, Sept. 2022, p. 3845. doi:10.3390/nu14183845. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501856/
Sripanidkulchai, Bungorn, et al. "Supplementation of Kaempferia Parviflora Extract Enhances Physical Fitness and Modulates Parameters of Heart Rate Variability in Adolescent Student-Athletes: A Randomized, Double-Blind, Placebo-Controlled Clinical Study." Journal of Dietary Supplements, vol. 19, no. 2, Mar. 2022, pp. 149–67. doi:10.1080/19390211.2020.1852356; https://www.tandfonline.com/doi/abs/10.1080/19390211.2020.1852356
Ongchai, Siriwan, et al. "Kaempferia Parviflora Extract Alleviated Rat Arthritis, Exerted Chondroprotective Properties In Vitro, and Reduced Expression of Genes Associated with Inflammatory Arthritis." Molecules, vol. 26, no. 6, Mar. 2021, p. 1527. doi:10.3390/molecules26061527; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000004/
Kobayashi, Hiroko, et al. "Effect of Kaempferia Parviflora Extract on Knee Osteoarthritis." Journal of Natural Medicines, vol. 72, no. 1, Jan. 2018, pp. 136–44. doi:10.1007/s11418-017-1121-6; https://link.springer.com/article/10.1007/s11418-017-1121-6
Sae-wong, Chutha, et al. "Anti-Inflammatory Mechanism of Kaempferia Parviflora in Murine Macrophage Cells (RAW 264.7) and in Experimental Animals." Journal of Ethnopharmacology, vol. 124, no. 3, July 2009, pp. 576–80. doi:10.1016/j.jep.2009.04.059; https://www.sciencedirect.com/science/article/abs/pii/S0378874109002876
Chen, Dalin et al. "Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities." Evidence-based complementary and alternative medicine vol. 2018 4057456. 16 Dec. 2018, doi:10.1155/2018/4057456 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311295/
Mango Extract (Mangifera indica)
López-Ríos, Laura, et al. "Central Nervous System Activities of Extract Mangifera Indica L." Journal of Ethnopharmacology, vol. 260, Oct. 2020, p. 112996, doi:10.1016/j.jep.2020.112996. https://www.sciencedirect.com/science/article/pii/S0378874119345416
Gerstgrasser, Alexandra et al. "In Vitro Activation of eNOS by Mangifera indica (Careless™) and Determination of an Effective Dosage in a Randomized, Double-Blind, Human Pilot Study on Microcirculation." Planta medica vol. 82,4 (2016): 298-304. doi:10.1055/s-0035-1558219. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1558219
Antioxidants & Phenolic Compounds
Grape Seed Extract & Proanthocyanidins
Fitzpatrick, David F., et al. "Isolation and Characterization of Endothelium-Dependent Vasorelaxing Compounds from Grape Seeds." Journal of Agricultural and Food Chemistry, vol. 48, no. 12, Dec. 2000, pp. 6384–90. doi:10.1021/jf0009347; https://pubs.acs.org/doi/10.1021/jf0009347
Rauf, Abdur, et al. "Proanthocyanidins: A Comprehensive Review." Biomedicine & Pharmacotherapy, vol. 116, Aug. 2019, p. 108999. doi:10.1016/j.biopha.2019.108999; https://www.sciencedirect.com/science/article/pii/S0753332219305359
Wang, Tsz Ki et al. "Proanthocyanidins Should Be a Candidate in the Treatment of Cancer, Cardiovascular Diseases and Lipid Metabolic Disorder." Molecules vol. 25,24 5971. 16 Dec. 2020, doi:10.3390/molecules25245971. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766935/
Phenolic Acids
Lutz, Mariane et al. "Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases." Molecules vol. 24,2 366. 21 Jan. 2019, doi:10.3390/molecules24020366. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359321/
Kumar, Naresh, and Nidhi Goel. "Phenolic acids: Natural versatile molecules with promising therapeutic applications." Biotechnology reports vol. 24 e00370. 20 Aug. 2019, doi:10.1016/j.btre.2019.e00370. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734135/
Hormone Support & General Health
DHEA
El-Sakka, Ahmed I. "Dehydroepiandrosterone and Erectile Function: A Review." The World Journal of Men's Health, vol. 36, no. 3, 2018, p. 183, doi:10.5534/wjmh.180005. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119841/
Sripada, Rebecca K, et al. "DHEA Enhances Emotion Regulation Neurocircuits and Modulates Memory for Emotional Stimuli." Neuropsychopharmacology, vol. 38, no. 9, 3 Apr. 2013, pp. 1798–1807, doi:10.1038/npp.2013.79. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717538/
Samaras, Nikolaos, et al. "A Review of Age-Related Dehydroepiandrosterone Decline and Its Association with Well-Known Geriatric Syndromes: Is Treatment Beneficial?" Rejuvenation Research, vol. 16, no. 4, Aug. 2013, pp. 285–294, doi:10.1089/rej.2013.1425. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746247/
Grimley Evans, John, et al. "Dehydroepiandrosterone (DHEA) Supplementation for Cognitive Function in Healthy Elderly People." Cochrane Database of Systematic Reviews, 18 Oct. 2006, doi:10.1002/14651858.cd006221. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988513/
Farooqi, Nasr A.I., et al. "Role of DHEA and Cortisol in Prefrontal-Amygdalar Development and Working Memory." Psychoneuroendocrinology, vol. 98, Dec. 2018, pp. 86–94, doi:10.1016/j.psyneuen.2018.08.010. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204313/
DIM (3,3′-Diindolylmethane)
Thomson, Cynthia A., et al. "Chemopreventive Properties of 3,3′-Diindolylmethane in Breast Cancer: Evidence from Experimental and Human Studies." Nutrition Reviews, vol. 74, no. 7, 1 July 2016, pp. 432–443, doi:10.1093/nutrit/nuw010. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059820/
Sanderson, J. T., et al. "2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Diindolylmethanes Differentially Induce Cytochrome P450 1A1, 1B1, and 19 in H295R Human Adrenocortical Carcinoma Cells." Toxicological Sciences, vol. 61, no. 1, 1 May 2001, pp. 40–48, doi:10.1093/toxsci/61.1.40. https://pubmed.ncbi.nlm.nih.gov/11294972/
Szaefer, Hanna, et al. "Modulation of CYP1A1, CYP1A2 and CYP1B1 Expression by Cabbage Juices and Indoles in Human Breast Cell Lines." Nutrition and Cancer, vol. 64, no. 6, 1 Aug. 2012, pp. 879–888, doi:10.1080/01635581.2012.690928. https://pubmed.ncbi.nlm.nih.gov/22716309/
Vivar, Omar I., et al. "Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmethane." Endocrinology, vol. 151, no. 4, 16 Feb. 2010, pp. 1662–1667, doi:10.1210/en.2009-1028. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850231/
Kall, Morten A., et al. "Effects of Dietary Broccoli on Human in Vivo Drug Metabolizing Enzymes: Evaluation of Caffeine, Oestrone and Chlorzoxazone Metabolism." Carcinogenesis, vol. 17, no. 4, 1996, pp. 793–799, doi:10.1093/carcin/17.4.793. https://www.ncbi.nlm.nih.gov/pubmed/8625493/
Jellinck, P. H., et al. "Ah Receptor Binding Properties of Indole Carbinols and Induction of Hepatic Estradiol Hydroxylation." Biochemical Pharmacology, vol. 45, no. 5, 9 Mar. 1993, pp. 1129–1136, doi:10.1016/0006-2952(93)90258-x. https://pubmed.ncbi.nlm.nih.gov/8384853/
Napoli, Nicola, et al. "Increased 2-Hydroxylation of Estrogen Is Associated with Lower Body Fat and Increased Lean Body Mass in Postmenopausal Women." Maturitas, vol. 72, no. 1, May 2012, pp. 66–71, doi:10.1016/j.maturitas.2012.02.002. https://www.sciencedirect.com/science/article/abs/pii/S0378512212000552
Essential Minerals & Micronutrients
Boron
Pizzorno, L.; "Nothing Boring About Boron."; Integrative medicine (Encinitas, Calif.) vol. 14,4 (2015): 35-48; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/
Naghii MR, et al. "Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines."; J Trace Elem Med Biol. 2011;25(1):54-58. doi:10.1016/j.jtemb.2010.10.001. https://pubmed.ncbi.nlm.nih.gov/21129941/
Magnesium
Cinar, Vedat, et al. "Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion." Biological Trace Element Research, vol. 140, no. 1, 30 Mar. 2010, pp. 18–23, doi:10.1007/s12011-010-8676-3. https://pubmed.ncbi.nlm.nih.gov/20352370/
Maggio, Marcello, et al. "The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men." International Journal of Endocrinology, vol. 2014, 2014, pp. 1–9, doi:10.1155/2014/525249. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958794/
DiNicolantonio, James J, et al. "Subclinical Magnesium Deficiency: A Principal Driver of Cardiovascular Disease and a Public Health Crisis." Open Heart, vol. 5, no. 1, Jan. 2018, p. e000668, doi:10.1136/openhrt-2017-000668. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/
Selenium
Altuhafi, Abdulateef, et al. "The Correlation between Selenium Dependent Glutathione Peroxidase Activity and Oxidant/Antioxidant Balance in Sera of Diabetic Patients with Nephropathy." Reports of Biochemistry and Molecular Biology, vol. 10, no. 2, 1 Aug. 2021, pp. 164–172, doi:10.52547/rbmb.10.2.164. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480288/
Ventura, Mara, et al. "Selenium and Thyroid Disease: From Pathophysiology to Treatment." International Journal of Endocrinology, vol. 2017, no. 1, 2017, pp. 1–9, doi:10.1155/2017/1297658. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307254/
Moslemi, Mohammad Kazem, and Seiied Ali Zargar. "Selenium–Vitamin E Supplementation in Infertile Men: Effects on Semen Parameters and Pregnancy Rate." International Journal of General Medicine, Jan. 2011, p. 99, doi:10.2147/ijgm.s16275. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048346/
Zinc
Prasad, Ananda S., et al. "Zinc Status and Serum Testosterone Levels of Healthy Adults." Nutrition, vol. 12, no. 5, May 1996, pp. 344–348, doi:10.1016/s0899-9007(96)80058-x. https://pubmed.ncbi.nlm.nih.gov/8875519/
wessels, inga, et al. "Zinc as a Gatekeeper of Immune Function." Nutrients, vol. 9, no. 12, 25 Nov. 2017, p. 1286, doi:10.3390/nu9121286. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748737/
Essential Vitamins
Vitamin D
Monson, Neetha R., et al. "Association between Vitamin D Deficiency and Testosterone Levels in Adult Males: A Systematic Review." Cureus, vol. 15, no. 9, 24 Sept. 2023, doi:10.7759/cureus.45856. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518189/
Ceglia, Lisa. "Vitamin D and Its Role in Skeletal Muscle." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 6, Nov. 2009, pp. 628–633, doi:10.1097/mco.0b013e328331c707. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901845/
General Research
Phytochemicals & Infertility
Chorosho, Saziini H., et al. "Phytochemicals: Alternative for Infertility Treatment and Associated Conditions." Oxidative Medicine and Cellular Longevity, vol. 2023, 11 May 2023, p. 1327562, doi:10.1155/2023/1327562. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195183/
STILL NOT SURE IF THIS IS FOR YOU?
Frequently Asked Questions
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Scientific Studies & References
Testosterone & Hormone Optimization
Tribulus Terrestris
Jones, Hugh. "Testosterone for the Aging Male; Current Evidence and Recommended Practice." Clinical Interventions in Aging, vol. Volume 3, no. 1, Mar. 2008, pp. 25–44, doi:10.2147/cia.s190. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544367/
Gauthaman, Kalamegam, et al. "Sexual Effects of Puncturevine (Tribulus Terrestris) Extract (Protodioscin): An Evaluation Using a Rat Model." The Journal of Alternative and Complementary Medicine, vol. 9, no. 2, Apr. 2003, pp. 257–265, doi:10.1089/10755530360623374. https://pubmed.ncbi.nlm.nih.gov/12804079/
Adaikan, P. G., et al. "History of Herbal Medicines with an Insight on the Pharmacological Properties Of Tribulus Terrestris." The Aging Male, vol. 4, no. 3, Jan. 2001, pp. 163–169, https://www.tandfonline.com/doi/abs/10.1080/tam.4.3.163.169
Ștefănescu, Ruxandra, et al. "A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus Terrestris L." Biomolecules, vol. 10, no. 5, 12 May 2020, p. 752, doi:10.3390/biom10050752. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277861/
Dinchev, Dragomir, et al. "Distribution of Steroidal Saponins in Tribulus Terrestris from Different Geographical Regions." Phytochemistry, vol. 69, no. 1, Jan. 2008, pp. 176–186, doi:10.1016/j.phytochem.2007.07.003. https://www.sciencedirect.com/science/article/abs/pii/S0031942207004657
Adimoelja, A., and P. Adaikan. "Protodioscin from Herbal Plant Tribulus Terrestris L Improves the Male Sexual Functions, Probably via DHEA." Semantic Scholar, 1997; https://www.semanticscholar.org/paper/Protodioscin-from-herbal-plant-Tribulus-terrestris-Adimoelja-Adaikan/1355db896a86c6cff7b69e057b48bd5cea96f241
Gauthaman, Kalamegam, and Adaikan P Ganesan. "The Hormonal Effects of Tribulus Terrestris and Its Role in the Management of Male Erectile Dysfunction–an Evaluation Using Primates, Rabbit and Rat." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 15, no. 1-2, 2008, pp. 44–54, https://www.ncbi.nlm.nih.gov/pubmed/18068966/
Fadogia Agrestis
Raman, Vijayasankar, et al. "Microscopic Characterization and HPTLC of the Leaves, Stems and Roots of Fadogia Agrestis – an African Folk Medicinal Plant." Revista Brasileira de Farmacognosia, vol. 28, 2018, pp. 631–639, https://doi.org/10.1016/j.bjp.2018.07.006
Yakubu, M T et al. "Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats." Asian journal of andrology vol. 7,4 (2005): 399-404. doi:10.1111/j.1745-7262.2005.00052.x https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1745-7262.2005.00052.x
Yakubu, Musa Toyin et al. "Effects of oral administration of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem on some testicular function indices of male rats." Journal of ethnopharmacology vol. 115,2 (2008): 288-92. doi:10.1016/j.jep.2007.10.004. https://www.sciencedirect.com/science/article/abs/pii/S0378874107005296
Tongkat Ali (Eurycoma longifolia)
Leitão, Alice Erwig et al. "A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM)." Maturitas vol. 145 (2021): 78-85; https://pubmed.ncbi.nlm.nih.gov/33541567/
Kotirum, Surachai, et al. "Efficacy of Tongkat Ali (Eurycoma Longifolia) on Erectile Function Improvement: Systematic Review and Meta-Analysis of Randomized Controlled Trials." Complementary Therapies in Medicine, vol. 23, no. 5, Oct. 2015, pp. 693–698, doi:10.1016/j.ctim.2015.07.009. https://pubmed.ncbi.nlm.nih.gov/26365449/
Leisegang, Kristian et al. "Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials." Medicina (Kaunas, Lithuania) vol. 58,8 1047. 4 Aug. 2022, doi:10.3390/medicina58081047. https://www.mdpi.com/1648-9144/58/8/1047
Talbott, Shawn M, et al. "Effect of Tongkat Ali on Stress Hormones and Psychological Mood State in Moderately Stressed Subjects." Journal of the International Society of Sports Nutrition, vol. 10, 26 May 2013, p. 28, doi:10.1186/1550-2783-10-28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669033/
Hamzah, Sareena and Yusof, Ashril. "The ergogenic effects of Tongkat ali (Eurycoma longifolia): A pilot study." British J Sports Med. 2003, vol. 37: 464-470. https://www.researchgate.net/publication/341998425_The_Ergogenic_Effect_of_Eurycoma_longifolia_Jack_A_Pilot_Study
Adaptogenic & Performance Herbs
Ashwagandha (Withania somnifera)
Chandrasekhar, K, et al; "A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults."; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; July 2012; https://www.ncbi.nlm.nih.gov/pubmed/23439798
Ahmad, Mohammad Kaleem, et al. "Withania Somnifera Improves Semen Quality by Regulating Reproductive Hormone Levels and Oxidative Stress in Seminal Plasma of Infertile Males." Fertility and Sterility, vol. 94, no. 3, 2010, pp. 989–96, doi:10.1016/j.fertnstert.2009.04.046. https://pubmed.ncbi.nlm.nih.gov/19501822/
Sandhu, Jaspal Singh, et al. "Effects of Withania Somnifera (Ashwagandha) and Terminalia Arjuna (Arjuna) on Physical Performance and Cardiorespiratory Endurance in Healthy Young Adults." International Journal of Ayurveda Research, vol. 1, no. 3, 2010, pp. 144–9, doi:10.4103/0974-7788.72485. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996571/
Maca (Lepidium meyenii)
Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska L; "Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content."; Menopause; 2008; 15(6); 1157–1162; https://pubmed.ncbi.nlm.nih.gov/18784609
Melnikovova, Ingrid, et al. "Effect OfLepidium MeyeniiWalp. On Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study." Evidence-Based Complementary and Alternative Medicine, vol. 2015, 2015, pp. 1–6, doi:10.1155/2015/324369. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569766/
Lee, Myeong Soo, et al. "The Use of Maca (Lepidium Meyenii) to Improve Semen Quality: A Systematic Review." Maturitas, vol. 92, 1 Oct. 2016, pp. 64–69, doi:10.1016/j.maturitas.2016.07.013. https://pubmed.ncbi.nlm.nih.gov/27621241/
Choi, E., et al; "Supplementation of Standardized Lipid-Soluble Extract from Maca (Lepidium Meyenii) Increases Swimming Endurance Capacity in Rats.";Journal of Functional Foods; Elsevier; 4 Apr. 2012; https://www.sciencedirect.com/science/article/pii/S1756464612000436
Jiannine, LM and Antonio, J.; "The Effects of Lepidium Meyenii on Grip Strength, Fatigue, and Sexual Behavior."; Journal of Exercise and Nutrition; 2019; 2(1); https://www.journalofexerciseandnutrition.com/ManuscriptUploadsPDF/72.pdf
Shilajit
Pandit, S., et al. "Clinical Evaluation of Purified Shilajit on Testosterone Levels in Healthy Volunteers." Andrologia, vol. 48, no. 5, 22 Sept. 2015, pp. 570–575, doi:10.1111/and.12482. https://onlinelibrary.wiley.com/doi/10.1111/and.12482
Safed Musli (Chlorophytum borivilianum)
Rath, SudiptaKumar, and AsitKumar Panja. "Clinical Evaluation of Root Tubers of Shweta Musali (Chlorophytum Borivilianum L.) and Its Effect on Semen and Testosterone." AYU (an International Quarterly Journal of Research in Ayurveda), vol. 34, no. 3, 2013, p. 273, doi:10.4103/0974-8520.123118. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902593/
Khanam, Zakia, et al. "Safed Musli (Chlorophytum Borivilianum): A Review of Its Botany, Ethnopharmacology and Phytochemistry." Journal of Ethnopharmacology, vol. 150, no. 2, Nov. 2013, pp. 421–441, doi:10.1016/j.jep.2013.08.064. https://pubmed.ncbi.nlm.nih.gov/24045177/
Vascular Health & Circulation
Horny Goat Weed (Epimedium/Icariin)
Chau, Yasmin, et al. "Exploration of Icariin Analog Structure Space Reveals Key Features Driving Potent Inhibition of Human Phosphodiesterase-5." PLOS ONE, vol. 14, no. 9, 20 Sept. 2019, p. e0222803, doi:10.1371/journal.pone.0222803. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754136/
Jin, Feng, et al. "Icariin, a Phoshphodiesterase-5 Inhibitor, Improves Learning and Memory in APP/PS1 Transgenic Mice by Stimulation of NO/CGMP Signalling." The International Journal of Neuropsychopharmacology, vol. 17, no. 06, 11 Feb. 2014, pp. 871–881, doi:10.1017/s1461145713001533. https://pubmed.ncbi.nlm.nih.gov/24513083/
Fang, Jian, and Yongjun Zhang. "Icariin, an Anti-Atherosclerotic Drug from Chinese Medicinal Herb Horny Goat Weed." Frontiers in Pharmacology, vol. 8, 12 Oct. 2017, doi:10.3389/fphar.2017.00734. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644024/
Xin, Z. C., et al. "Effects of Icariin on CGMP-Specific PDE5 and CAMP-Specific PDE4 Activities." Asian Journal of Andrology, vol. 5, no. 1, 1 Mar. 2003, pp. 15–18; https://pubmed.ncbi.nlm.nih.gov/12646997/
Zhang, Zhen-Bao, and Qing-Tao Yang. "The Testosterone Mimetic Properties of Icariin." Asian Journal of Andrology, vol. 8, no. 5, 1 Sept. 2006, pp. 601–605, doi:10.1111/j.1745-7262.2006.00197.x. https://pubmed.ncbi.nlm.nih.gov/16751992/
Wang, Pengzhen, et al. "Icariin Activates Far Upstream Element Binding Protein 1 to Regulate Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α Signaling and Benefits Chondrocytes." PeerJ, vol. 11, 22 Aug. 2023, pp. e15917–e15917, doi:10.7717/peerj.15917. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452614/
Lin, Yi-An et al. "Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy." Scientific reports vol. 11,1 10790. 24 May. 2021, doi:10.1038/s41598-021-89039-0 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144409/
Chen, Sui-Qing et al. "Icariin induces irisin/FNDC5 expression in C2C12 cells via the AMPK pathway." Biomedicine & pharmacotherapy vol. 115 (2019): 108930. doi:10.1016/j.biopha.2019.108930 https://www.sciencedirect.com/science/article/pii/S0753332219306973
Ginkgo Biloba
Mahadevan, S, and Y Park. "Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses." Journal of food science vol. 73,1 (2008): R14-9. doi:10.1111/j.1750-3841.2007.00597.x https://ift.onlinelibrary.wiley.com/doi/10.1111/j.1750-3841.2007.00597.x
Mehlsen, J., et al. "Effects of a Ginkgo Biloba Extract on Forearm Haemodynamics in Healthy Volunteers." Clinical Physiology and Functional Imaging, vol. 22, no. 6, Nov. 2002, pp. 375–78. doi:10.1046/j.1475-097x.2002.00445.x; https://pubmed.ncbi.nlm.nih.gov/12464140/
Silva, Henrique, and Filipe Gazalho Martins. "Cardiovascular Activity of Ginkgo Biloba—An Insight from Healthy Subjects." Biology, vol. 12, no. 1, Dec. 2022, p. 15. doi:10.3390/biology12010015; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855530/
Mashayekh, Ameneh et al. "Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study." Neuroradiology vol. 53,3 (2011): 185-91. doi:10.1007/s00234-010-0790-6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163160/
Eisvand, Farhad, et al. "The Effects of Ginkgo Biloba on Metabolic Syndrome: A Review." Phytotherapy Research, vol. 34, no. 8, Aug. 2020, pp. 1798–811. doi:10.1002/ptr.6646; https://www.ncbi.nlm.nih.gov/pubmed/32097990
Black Ginger (Kaempferia parviflora)
Lee, Sunkyu, et al. "Standardized Kaempferia Parviflora Wall. Ex Baker (Zingiberaceae) Extract Inhibits Fat Accumulation and Muscle Atrophy in Ob/Ob Mice." Evidence-Based Complementary and Alternative Medicine, vol. 2018, May 2018, p. 8161042. doi:10.1155/2018/8161042; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994587/
Toda, Kazuya, et al. "Black Ginger Extract Increases Physical Fitness Performance and Muscular Endurance by Improving Inflammation and Energy Metabolism." Heliyon, vol. 2, no. 5, May 2016, p. e00115. doi:10.1016/j.heliyon.2016.e00115. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946221/
Huang, Jiapeng, et al. "Black Ginger (Kaempferia Parviflora) Extract Enhances Endurance Capacity by Improving Energy Metabolism and Substrate Utilization in Mice." Nutrients, vol. 14, no. 18, Sept. 2022, p. 3845. doi:10.3390/nu14183845. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501856/
Sripanidkulchai, Bungorn, et al. "Supplementation of Kaempferia Parviflora Extract Enhances Physical Fitness and Modulates Parameters of Heart Rate Variability in Adolescent Student-Athletes: A Randomized, Double-Blind, Placebo-Controlled Clinical Study." Journal of Dietary Supplements, vol. 19, no. 2, Mar. 2022, pp. 149–67. doi:10.1080/19390211.2020.1852356; https://www.tandfonline.com/doi/abs/10.1080/19390211.2020.1852356
Ongchai, Siriwan, et al. "Kaempferia Parviflora Extract Alleviated Rat Arthritis, Exerted Chondroprotective Properties In Vitro, and Reduced Expression of Genes Associated with Inflammatory Arthritis." Molecules, vol. 26, no. 6, Mar. 2021, p. 1527. doi:10.3390/molecules26061527; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000004/
Kobayashi, Hiroko, et al. "Effect of Kaempferia Parviflora Extract on Knee Osteoarthritis." Journal of Natural Medicines, vol. 72, no. 1, Jan. 2018, pp. 136–44. doi:10.1007/s11418-017-1121-6; https://link.springer.com/article/10.1007/s11418-017-1121-6
Sae-wong, Chutha, et al. "Anti-Inflammatory Mechanism of Kaempferia Parviflora in Murine Macrophage Cells (RAW 264.7) and in Experimental Animals." Journal of Ethnopharmacology, vol. 124, no. 3, July 2009, pp. 576–80. doi:10.1016/j.jep.2009.04.059; https://www.sciencedirect.com/science/article/abs/pii/S0378874109002876
Chen, Dalin et al. "Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities." Evidence-based complementary and alternative medicine vol. 2018 4057456. 16 Dec. 2018, doi:10.1155/2018/4057456 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311295/
Mango Extract (Mangifera indica)
López-Ríos, Laura, et al. "Central Nervous System Activities of Extract Mangifera Indica L." Journal of Ethnopharmacology, vol. 260, Oct. 2020, p. 112996, doi:10.1016/j.jep.2020.112996. https://www.sciencedirect.com/science/article/pii/S0378874119345416
Gerstgrasser, Alexandra et al. "In Vitro Activation of eNOS by Mangifera indica (Careless™) and Determination of an Effective Dosage in a Randomized, Double-Blind, Human Pilot Study on Microcirculation." Planta medica vol. 82,4 (2016): 298-304. doi:10.1055/s-0035-1558219. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1558219
Antioxidants & Phenolic Compounds
Grape Seed Extract & Proanthocyanidins
Fitzpatrick, David F., et al. "Isolation and Characterization of Endothelium-Dependent Vasorelaxing Compounds from Grape Seeds." Journal of Agricultural and Food Chemistry, vol. 48, no. 12, Dec. 2000, pp. 6384–90. doi:10.1021/jf0009347; https://pubs.acs.org/doi/10.1021/jf0009347
Rauf, Abdur, et al. "Proanthocyanidins: A Comprehensive Review." Biomedicine & Pharmacotherapy, vol. 116, Aug. 2019, p. 108999. doi:10.1016/j.biopha.2019.108999; https://www.sciencedirect.com/science/article/pii/S0753332219305359
Wang, Tsz Ki et al. "Proanthocyanidins Should Be a Candidate in the Treatment of Cancer, Cardiovascular Diseases and Lipid Metabolic Disorder." Molecules vol. 25,24 5971. 16 Dec. 2020, doi:10.3390/molecules25245971. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766935/
Phenolic Acids
Lutz, Mariane et al. "Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases." Molecules vol. 24,2 366. 21 Jan. 2019, doi:10.3390/molecules24020366. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359321/
Kumar, Naresh, and Nidhi Goel. "Phenolic acids: Natural versatile molecules with promising therapeutic applications." Biotechnology reports vol. 24 e00370. 20 Aug. 2019, doi:10.1016/j.btre.2019.e00370. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734135/
Hormone Support & General Health
DHEA
El-Sakka, Ahmed I. "Dehydroepiandrosterone and Erectile Function: A Review." The World Journal of Men's Health, vol. 36, no. 3, 2018, p. 183, doi:10.5534/wjmh.180005. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119841/
Sripada, Rebecca K, et al. "DHEA Enhances Emotion Regulation Neurocircuits and Modulates Memory for Emotional Stimuli." Neuropsychopharmacology, vol. 38, no. 9, 3 Apr. 2013, pp. 1798–1807, doi:10.1038/npp.2013.79. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717538/
Samaras, Nikolaos, et al. "A Review of Age-Related Dehydroepiandrosterone Decline and Its Association with Well-Known Geriatric Syndromes: Is Treatment Beneficial?" Rejuvenation Research, vol. 16, no. 4, Aug. 2013, pp. 285–294, doi:10.1089/rej.2013.1425. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746247/
Grimley Evans, John, et al. "Dehydroepiandrosterone (DHEA) Supplementation for Cognitive Function in Healthy Elderly People." Cochrane Database of Systematic Reviews, 18 Oct. 2006, doi:10.1002/14651858.cd006221. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988513/
Farooqi, Nasr A.I., et al. "Role of DHEA and Cortisol in Prefrontal-Amygdalar Development and Working Memory." Psychoneuroendocrinology, vol. 98, Dec. 2018, pp. 86–94, doi:10.1016/j.psyneuen.2018.08.010. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204313/
DIM (3,3′-Diindolylmethane)
Thomson, Cynthia A., et al. "Chemopreventive Properties of 3,3′-Diindolylmethane in Breast Cancer: Evidence from Experimental and Human Studies." Nutrition Reviews, vol. 74, no. 7, 1 July 2016, pp. 432–443, doi:10.1093/nutrit/nuw010. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059820/
Sanderson, J. T., et al. "2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Diindolylmethanes Differentially Induce Cytochrome P450 1A1, 1B1, and 19 in H295R Human Adrenocortical Carcinoma Cells." Toxicological Sciences, vol. 61, no. 1, 1 May 2001, pp. 40–48, doi:10.1093/toxsci/61.1.40. https://pubmed.ncbi.nlm.nih.gov/11294972/
Szaefer, Hanna, et al. "Modulation of CYP1A1, CYP1A2 and CYP1B1 Expression by Cabbage Juices and Indoles in Human Breast Cell Lines." Nutrition and Cancer, vol. 64, no. 6, 1 Aug. 2012, pp. 879–888, doi:10.1080/01635581.2012.690928. https://pubmed.ncbi.nlm.nih.gov/22716309/
Vivar, Omar I., et al. "Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmethane." Endocrinology, vol. 151, no. 4, 16 Feb. 2010, pp. 1662–1667, doi:10.1210/en.2009-1028. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850231/
Kall, Morten A., et al. "Effects of Dietary Broccoli on Human in Vivo Drug Metabolizing Enzymes: Evaluation of Caffeine, Oestrone and Chlorzoxazone Metabolism." Carcinogenesis, vol. 17, no. 4, 1996, pp. 793–799, doi:10.1093/carcin/17.4.793. https://www.ncbi.nlm.nih.gov/pubmed/8625493/
Jellinck, P. H., et al. "Ah Receptor Binding Properties of Indole Carbinols and Induction of Hepatic Estradiol Hydroxylation." Biochemical Pharmacology, vol. 45, no. 5, 9 Mar. 1993, pp. 1129–1136, doi:10.1016/0006-2952(93)90258-x. https://pubmed.ncbi.nlm.nih.gov/8384853/
Napoli, Nicola, et al. "Increased 2-Hydroxylation of Estrogen Is Associated with Lower Body Fat and Increased Lean Body Mass in Postmenopausal Women." Maturitas, vol. 72, no. 1, May 2012, pp. 66–71, doi:10.1016/j.maturitas.2012.02.002. https://www.sciencedirect.com/science/article/abs/pii/S0378512212000552
Essential Minerals & Micronutrients
Boron
Pizzorno, L.; "Nothing Boring About Boron."; Integrative medicine (Encinitas, Calif.) vol. 14,4 (2015): 35-48; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/
Naghii MR, et al. "Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines."; J Trace Elem Med Biol. 2011;25(1):54-58. doi:10.1016/j.jtemb.2010.10.001. https://pubmed.ncbi.nlm.nih.gov/21129941/
Magnesium
Cinar, Vedat, et al. "Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion." Biological Trace Element Research, vol. 140, no. 1, 30 Mar. 2010, pp. 18–23, doi:10.1007/s12011-010-8676-3. https://pubmed.ncbi.nlm.nih.gov/20352370/
Maggio, Marcello, et al. "The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men." International Journal of Endocrinology, vol. 2014, 2014, pp. 1–9, doi:10.1155/2014/525249. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958794/
DiNicolantonio, James J, et al. "Subclinical Magnesium Deficiency: A Principal Driver of Cardiovascular Disease and a Public Health Crisis." Open Heart, vol. 5, no. 1, Jan. 2018, p. e000668, doi:10.1136/openhrt-2017-000668. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/
Selenium
Altuhafi, Abdulateef, et al. "The Correlation between Selenium Dependent Glutathione Peroxidase Activity and Oxidant/Antioxidant Balance in Sera of Diabetic Patients with Nephropathy." Reports of Biochemistry and Molecular Biology, vol. 10, no. 2, 1 Aug. 2021, pp. 164–172, doi:10.52547/rbmb.10.2.164. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480288/
Ventura, Mara, et al. "Selenium and Thyroid Disease: From Pathophysiology to Treatment." International Journal of Endocrinology, vol. 2017, no. 1, 2017, pp. 1–9, doi:10.1155/2017/1297658. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307254/
Moslemi, Mohammad Kazem, and Seiied Ali Zargar. "Selenium–Vitamin E Supplementation in Infertile Men: Effects on Semen Parameters and Pregnancy Rate." International Journal of General Medicine, Jan. 2011, p. 99, doi:10.2147/ijgm.s16275. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048346/
Zinc
Prasad, Ananda S., et al. "Zinc Status and Serum Testosterone Levels of Healthy Adults." Nutrition, vol. 12, no. 5, May 1996, pp. 344–348, doi:10.1016/s0899-9007(96)80058-x. https://pubmed.ncbi.nlm.nih.gov/8875519/
wessels, inga, et al. "Zinc as a Gatekeeper of Immune Function." Nutrients, vol. 9, no. 12, 25 Nov. 2017, p. 1286, doi:10.3390/nu9121286. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748737/
Essential Vitamins
Vitamin D
Monson, Neetha R., et al. "Association between Vitamin D Deficiency and Testosterone Levels in Adult Males: A Systematic Review." Cureus, vol. 15, no. 9, 24 Sept. 2023, doi:10.7759/cureus.45856. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518189/
Ceglia, Lisa. "Vitamin D and Its Role in Skeletal Muscle." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 6, Nov. 2009, pp. 628–633, doi:10.1097/mco.0b013e328331c707. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901845/
General Research
Phytochemicals & Infertility
Chorosho, Saziini H., et al. "Phytochemicals: Alternative for Infertility Treatment and Associated Conditions." Oxidative Medicine and Cellular Longevity, vol. 2023, 11 May 2023, p. 1327562, doi:10.1155/2023/1327562. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195183/
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